Liver resection for hepatocellular carcinoma in patients with cirrhosis
| العنوان: | Liver resection for hepatocellular carcinoma in patients with cirrhosis |
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| المؤلفون: | Chen Jt, Shao-Bin Cheng, F.‐K. P'eng, Cheng-Chung Wu, Tse-Jia Liu, Ho Wm |
| المصدر: | British Journal of Surgery. 92:348-355 |
| بيانات النشر: | Oxford University Press (OUP), 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Adult, Liver Cirrhosis, Male, medicine.medical_specialty, Carcinoma, Hepatocellular, Cirrhosis, Blood transfusion, medicine.medical_treatment, Gastroenterology, Asymptomatic, Preoperative care, Disease-Free Survival, Internal medicine, Preoperative Care, medicine, Carcinoma, Humans, Stage (cooking), Survival rate, Aged, Aged, 80 and over, Postoperative Care, business.industry, Liver Neoplasms, Middle Aged, medicine.disease, Treatment Outcome, Hepatocellular carcinoma, Female, Surgery, medicine.symptom, business |
| الوصف: | Background Although liver resection is now a safe procedure, its role for hepatocellular carcinoma (HCC) in patients with cirrhosis remains controversial. Methods This study compared the results of liver resection for HCC in patients with cirrhosis over two time intervals. One hundred and sixty-one patients had resection during period 1 (1991–1996) and 265 in period 2 (1997–2002). Early and long-term results after liver resection in the two periods were compared, and clinicopathological characteristics that influenced survival were identified. Results Tumour size was smaller, indocyanine green retention rate was higher, patients were older and a greater proportion of patients were asymptomatic in period 2 than period 1. Operative blood loss, need for blood transfusion, operative mortality rate, postoperative hospital stay and total hospital costs were significantly reduced in period 2. The 5-year disease-free survival rates were 28·2 and 33·9 per cent in periods 1 and 2 respectively (P = 0·042), and 5-year overall survival rates were 45·9 and 61·2 per cent (P < 0·001). Multivariate analysis identified serum α-fetoprotein level, need for blood transfusion and Union Internacional Contra la Cancrum tumour node metastasis stage as independent determinants of disease-free and overall survival. Conclusion The results of liver resection for HCC in patients with cirrhosis improved over time. Liver resection remains a good treatment option in selected patients with HCC arising from a cirrhotic liver. |
| تدمد: | 1365-2168 0007-1323 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::283fa936bde92a0f5912eb12adf51dc0Test https://doi.org/10.1002/bjs.4838Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....283fa936bde92a0f5912eb12adf51dc0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652168 00071323 |
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