Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial
| العنوان: | Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomised controlled trial |
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| المؤلفون: | J.G.Z. van Uffelen, M.J.M. Chinapaw, W. van Mechelen, Marijke Hopman-Rock |
| المساهمون: | Public and occupational health, EMGO - Musculoskeletal health, EMGO - Quality of care, TNO Kwaliteit van Leven |
| المصدر: | van Uffelen, J G Z, Chin A Paw, M J M, van Mechelen, W & Hopman-Rock, M 2008, ' Walking or vitamin B for cognition in older adults with mild cognitive impairment? A randomized controlled trial ', British Journal of Sports Medicine, vol. 42, no. 5, pp. 344-351 . https://doi.org/10.1136/bjsm.2007.044735Test British Journal of Sports Medicine, 5, 42, 344-351 British Journal of Sports Medicine, 42(5), 344-351 |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | cognition, Male, double blind procedure, Walking, Neuropsychological Tests, law.invention, chemistry.chemical_compound, Randomized controlled trial, law, cognitive defect, Orthopedics and Sports Medicine, sleep disorder, Netherlands, Aged, 80 and over, medicine.diagnostic_test, article, clinical trial, memory disorder, General Medicine, cyanocobalamin plus folic acid plus pyridoxine, Exercise Therapy, Vitamin B 12, aerobic exercise, Treatment Outcome, Health, drug withdrawal, Pill, Leefomgeving en gezondheid, health program, Female, patient participation, Vitamin, medicine.medical_specialty, sex difference, Physical Therapy, Sports Therapy and Rehabilitation, Verbal learning, Placebo, Folic Acid, Double-Blind Method, Memory, medicine, Aerobic exercise, Humans, controlled study, human, Aged, Mini–Mental State Examination, controlled clinical trial, business.industry, elderly care, mini mental state examination, vitamin supplementation, vitamin B complex, major clinical study, Vitamin B 6, attention, Clinical trial, chemistry, randomized controlled trial, placebo, Physical therapy, Patient Compliance, business, Cognition Disorders |
| الوصف: | Objective: To examine the effects of aerobic exercise or vitamin B supplementation on cognitive function in older adults with mild cognitive impairment (MCI). Design: Randomised placebo-controlled trial. Setting: General community. Participants: Community-dwelling adults aged 70-80 with MCI. Interventions : The 152 participants were randomly assigned to two interventions: (1) a twice-weekly, group-based, moderate-intensity walking programme (WP, n = 77) or a low-intensity placebo activity programme (n = 75) for one year; and (2) daily vitamin pill containing 5 mg folic acid, 0.4 mg vitamin B-12, 50 mg vitamin B-6 (FA/B12/B6, n = 78) or placebo pill (n = 74) for one year. Outcome measures: Cognitive function, measured with neuropsychological tests at baseline and after six and 12 months. Results: Median session attendance at the exercise programmes (25th-75th percentile) was 63% (2%-81%) and median compliance with taking pills (25th-75th percentile) was 100% (99%-100%). Gender was an effect modifier. Intention-to-treat analysis revealed no main intervention effect for either intervention. In women in the WP, attention (Stroop combination task) improved by 0.3 seconds (p = 0.04) and memory (auditory verbal learning test) by 0.04 words (p = 0.06) with each percentage increase in session attendance. In men attending at least 75% of the sessions, the WP improved memory (β 1.5 (95% CI: 0.1 to 3.0) words). Conclusion: The walking programme and/or FA/B12/B6 supplementation were not effective in improving cognition within one year. The walking programme, however, was efficacious in improving memory in men and memory and attention in women with better adherence. Trial registration: International Standard Randomised Controlled Trial Number Register, 19227688, http://www.controlled-trials.com/isrctnTest/. Chemicals / CAS: Folic Acid, 59-30-3; Vitamin B 12, 68-19-9; Vitamin B 6, 8059-24-3 |
| وصف الملف: | Print-Electronic; application/pdf |
| تدمد: | 1473-0480 0306-3674 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16c272a4f5860b9c45e936e681bb2a6Test https://pubmed.ncbi.nlm.nih.gov/18308888Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b16c272a4f5860b9c45e936e681bb2a6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14730480 03063674 |
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