التفاصيل البيبلوغرافية
| العنوان: |
A quantitative analysis of 1H-MR spectroscopy at 3.0 T of three brain regions from childhood to middle age. |
| المؤلفون: |
Z.-Y. YANG, Q. YUE, H.-Y. XING, Q.-Y. TAN, H.-Q. SUN, Q.-Y. GONG, Z.-J. TAN, H. QUAN |
| المصدر: |
British Journal of Radiology; Aug2015, Vol. 88 Issue 1052, p1-10, 10p |
| مصطلحات موضوعية: |
PROTON magnetic resonance spectroscopy, HIPPOCAMPUS (Brain), THALAMUS, BRAIN imaging, CREATINE, GLIOSIS |
| مستخلص: |
Objective: To study age-related metabolic changes in different brain regions. Methods: Point-resolved spectroscopy (repetition time/echo time = 2000ms/30ms) was performed in the left and right hippocampus, the left thalamus and the left centrum semiovale of 80 healthy subjects (37 females and 43 males aged 7-64 years). Analysis of covariance and linear regression were used for statistical analysis. Both metabolite concentration ratios with respect to total creatine (tCr) and absolute metabolite concentrations were included for analysis. Results: Ins (myo-inositol)/tCr (p<0.001) and absolute Ins concentration (p = 0.031) were significantly increased with age after adolescence. NAA (N-acetylaspartic acid)/tCr (p < 0.001) and absolute NAA concentration (p - 0.010) significantly declined with age after adolescence. Conclusion: Age-related increase of Ins and decline of NAA are found in all three regions, especially at the hippocampus, indicating possible gliosis in the ageing brain. Advances in knowledge: We could use NAA/tCr and Ins/ tCr as an indicator to estimate the neurons-to-glial cells ratio at the thalamus. This may be an index to distinguish normal tissues from gliosis. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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