The Platelet α2-Adrenoceptor as a Potential Biological Marker in Depression
| العنوان: | The Platelet α2-Adrenoceptor as a Potential Biological Marker in Depression |
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| المؤلفون: | Jesús A. García-Sevilla |
| المصدر: | British Journal of Psychiatry. 154:67-72 |
| بيانات النشر: | Royal College of Psychiatrists, 1989. |
| سنة النشر: | 1989 |
| مصطلحات موضوعية: | Adrenergic receptor, business.industry, Pharmacology, 030227 psychiatry, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Text mining, Medicine, Alpha-2 adrenergic receptor, Platelet, 030212 general & internal medicine, business, Depression (differential diagnoses) |
| الوصف: | Insights into the cellular and molecular mechanisms of action of anti-depressant drugs have led to the study of possible dysfunctions of monoamine neurotransmitter receptors in endogenous depression. Presynaptic receptors play an important role in the regulation of transmitter release from neurons. The major mechanism that regulates the release of noradrenaline appears to be feedback inhibition by the neurotransmitter located in the synaptic cleft. This inhibition is mediated by stimulation of a presynaptic autoreceptor, the inhibitory α2-adrenoceptor. When this is stimulated, further release of noradrenaline is inhibited; therefore, increased autoreceptor sensitivity could result in insufficient neuronal release of noradrenaline, and lead to depression. |
| تدمد: | 1472-1465 0007-1250 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::b8bb9855f8da16c57f4bd348fd7be6a0Test https://doi.org/10.1192/s0007125000295810Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........b8bb9855f8da16c57f4bd348fd7be6a0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14721465 00071250 |
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