Evidence for Allelic Heterogeneity in Familial Early-Onset Alzheimer's Disease
| العنوان: | Evidence for Allelic Heterogeneity in Familial Early-Onset Alzheimer's Disease |
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| المؤلفون: | J.J. Martin, John Hardy, Alison Goate, Martin N. Rossor, C. Van Broeckhoven, A. Hofman, Antoon Vandenberghe, C M van Duijn, Michael Mullan |
| المصدر: | The British journal of psychiatry Scopus-Elsevier |
| بيانات النشر: | Royal College of Psychiatrists, 1991. |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | Genetic Markers, Chromosomes, Human, Pair 21, Genetic Linkage, Genetic counseling, Population, Chromosome Disorders, Locus (genetics), Biology, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Risk Factors, Genetic linkage, medicine, Humans, Early-onset Alzheimer's disease, 030212 general & internal medicine, Allele, education, Alleles, Aged, Genes, Dominant, Chromosome Aberrations, Genetics, education.field_of_study, Models, Genetic, Genetic Carrier Screening, Middle Aged, medicine.disease, 030227 psychiatry, Psychiatry and Mental health, Allelic heterogeneity, Age of onset |
| الوصف: | Age of onset was examined for 139 members of 30 families affected by early-onset AD. Most (77%) of the variance of age of onset derived from differences between rather than within families. The constancy of age of onset within families was also observed in an analysis restricted to families derived from a population-based epidemiological study with complete ascertainment of early-onset AD. Furthermore, we observed clustering of age of onset within those families that support linkage to the predisposing locus on chromosome 21. Our data are compatible with the view that allelic heterogeneity at the AD locus may account for the similarity in age of onset within families. This finding may be of value for scientific studies of AD as well as for genetic counselling. |
| تدمد: | 1472-1465 0007-1250 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c70ad08011c348c79b3f8050ef157e93Test https://doi.org/10.1192/bjp.158.4.471Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c70ad08011c348c79b3f8050ef157e93 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14721465 00071250 |
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