التفاصيل البيبلوغرافية
| العنوان: |
Role of methylene blue-treated or fresh-frozen plasma in the response to plasma exchange in patients with thrombotic thrombocytopenic purpura. |
| المؤلفون: |
de la Rubia, Javier1, Arriaga, Francisco1, Linares, Dolores1, Larrea, Luis1, Carpio, Nelly1, Marty, María L.1, Sanz, Miguel A.1 |
| المصدر: |
British Journal of Haematology. Sep2001, Vol. 114 Issue 3, p721-723. 3p. 2 Charts. |
| مصطلحات موضوعية: |
*THROMBOTIC thrombocytopenic purpura treatment, *PLASMA exchange (Therapeutics) |
| مستخلص: |
Twenty patients with thrombotic thrombocytopenic purpura (TTP) underwent plasma exchange using either standard fresh-frozen plasma (Group A, n = 13) or methylene blue-treated plasma (Group B, n = 7). Both groups presented similar characteristics except that bilirubin values were higher in Group A (P < 0·05). The complete remission rate was higher in Group A than B (69% versus 57%). The mean number of procedures was higher in Group B (21 ± 7 versus 11 ± 3, P < 0·01) and the mean duration of hospitalization was also longer (37 ± 12 d versus 22 ± 11 d; P < 0·01). Our study shows that the use of methylene blue-treated fresh-frozen plasma to treat TTP is associated with a higher number of plasma exchanges and greater transfusion requirements without improving clinical results. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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