التفاصيل البيبلوغرافية
| العنوان: |
Favourable effect of the combination of acute and chronic graft-versus-host disease on the outcome of allogeneic peripheral blood stem cell transplantation for advanced haematological malignancies. |
| المؤلفون: |
Brunet, Salut, Urbano-Ispizua, Alvaro, Ojeda, Emilio, Ruiz, Dolores, Moraleda, José Ma., Díaz, Miguel Angel, Caballero, Dolores, Bargay, Joan, de la Rubia, Javier, Solano, Carlos, Zuazu, Javier, Diez, José Luis, de la Serna, Javier, Espigado, Idelfonso, Alegre, Adrián, Torres, J. Pio, Jurado, Manuel, Fernández, Manuel, Vivancos, Pilar, Carreras, Enric |
| المصدر: |
British Journal of Haematology; Sep2001, Vol. 114 Issue 3, p544-550, 7p, 4 Charts, 2 Graphs |
| مصطلحات موضوعية: |
GRAFT versus host disease, HEMATOPOIETIC stem cell transplantation, HEMATOLOGICAL oncology |
| مستخلص: |
To assess the influence of graft-versus-host disease (GVHD) on the outcome of patients with advanced haematological malignancies (AHM) who received a primary, unmodified allogeneic peripheral blood progenitor cells transplant (allo-PBT) from a human leucocyte antigen (HLA) identical sibling donor, we analysed 136 patients with myeloid neoplasms (n = 70) or lymphoproliferative disorders (n = 66), transplanted at 19 Spanish institutions. Median age was 35 years (range 1–61). The cumulative incidence of relapse for all patients was 34% (95% CI, 26–42%), 41% (95% CI, 33–49) for patients without GVHD and 14% (95% CI, 3–25) (P = 0·001) for patients with acute and chronic GVHD. After a median follow-up of 11 months (range 2–49), 60 (44%) patients remained alive with an actuarial probability of overall survival and disease-free survival (DFS) at 30 months of 31% (95% CI, 21–41%) and 28% (95% CI, 17–39%) respectively. In patients surviving > 100 d, the low incidence of relapse in those with acute and chronic GVHD led to a DFS of 57% (95% CI, 38–76%) compared with a DFS of 34% (95% CI, 17–51%) in the remaining patients (P = 0·03). Our results indicate a reduced incidence of relapse for patients with AHM receiving an unmodified allo-PBT and developing acute and chronic GVHD, which results in an improved DFS. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
