Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers
| العنوان: | Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers |
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| المؤلفون: | Yayoi Shikama, Hiroshi Ogata, Osamu Abe, Shingen Misaka, Hirooki Yabe, Yuko Ono, Tomoyuki Ono, Martin F. Fromm, Kenju Shimomura, Itaru Miura |
| المصدر: | Br J Clin Pharmacol |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | genetic structures, Pharmacology, Epigallocatechin gallate, 030226 pharmacology & pharmacy, Catechin, Eating, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Short Reports, Pharmacokinetics, Nadolol, Oral administration, medicine, Humans, Ingestion, Pharmacology (medical), 030212 general & internal medicine, Cross-Over Studies, Tea, business.industry, Crossover study, Healthy Volunteers, Bioavailability, chemistry, Concomitant, business, medicine.drug |
| الوصف: | AIMS: The aim of this study was to investigate the effects of a single green tea (GT), administered concomitantly or 1 hour before nadolol intake on nadolol pharmacokinetics. METHODS: In a randomized 3‐phase crossover study, 11 healthy volunteers received an oral administration of nadolol with, or 1 hour after preingestion of brewed GT, or with water in a volume of 150 mL. RESULTS: Geometric mean ratio with 90% confidence interval for nadolol AUC(0–48) was 0.371 (0.303–0.439) with concomitant GT. In addition, ingestion of GT 1 hour before nadolol administration resulted in a significant reduction of nadolol AUC(0–48) with geometric mean ratio of 0.536 (0.406–0.665). There were no differences in time to maximal plasma concentration and renal clearance of nadolol among groups. CONCLUSION: These results suggest that single concomitant ingestion of GT substantially decreases plasma concentrations of nadolol. Moreover, the reduction in nadolol bioavailability could persist for at least 1 hour after drinking a cup of GT. |
| تدمد: | 1365-2125 0306-5251 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09518916cedd27a6477a251888981788Test https://doi.org/10.1111/bcp.14315Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....09518916cedd27a6477a251888981788 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13652125 03065251 |
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