التفاصيل البيبلوغرافية
| العنوان: |
Pharmacokinetics of oral vs. intravenous dexamethasone in patients hospitalized with community-acquired pneumonia. |
| المؤلفون: |
Spoorenberg, Simone M. C., Deneer, Vera H. M., Grutters, Jan C., Pulles, Astrid E., Voorn, G. P. (Paul), Rijkers, Ger T., Bos, Willem Jan W., Garde, Ewoudt M. W. |
| المصدر: |
British Journal of Clinical Pharmacology; Jul2014, Vol. 78 Issue 1, p78-83, 6p |
| مصطلحات موضوعية: |
PHARMACOKINETICS, DEXAMETHASONE, COMMUNITY-acquired pneumonia, ADRENOCORTICAL hormones, HORMONE therapy, ORAL drug administration, INTRAVENOUS injections, BIOAVAILABILITY, THERAPEUTICS |
| مستخلص: |
Aim The use of corticosteroids as adjunctive therapy might be effective in patients with community-acquired pneumonia (CAP). Oral administration of dexamethasone is a practical and safer alternative to the intravenous route. Since patients hospitalized with pneumonia might have delayed gastric emptying, this study explored systemic exposure in terms of area under the concentration-time curve (AUC) of oral dexamethasone in patients hospitalized with CAP. Methods In this randomized, open label study, 30 patients admitted with CAP were randomized to receive either 4 mg intravenous or 6 mg oral dexamethasone for 4 consecutive days. Serial blood samples were obtained before and after drug administration. Results Median AUC to infinity was 626 μg l−1 h ( IQR 401-1161) for the intravenous group and 774 μg l−1 h ( IQR 618-1146) for the oral group. The AUC ratio of 6 mg oral and 4 mg intravenous dexamethasone was 1.22 (95% confidence interval ( CI) 0.81, 1.82), which represents a bioavailability of 81% (95% CI 54, 121) after correction for differences in dexamethasone dose. Conclusions Bioavailability of oral dexamethasone in patients hospitalized with pneumonia is sufficient. This makes oral dexamethasone an appropriate alternative for intravenous administration in these patients. [ABSTRACT FROM AUTHOR] |
|
Copyright of British Journal of Clinical Pharmacology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder