التفاصيل البيبلوغرافية
| العنوان: |
New treatments for autosomal dominant polycystic kidney disease. |
| المؤلفون: |
Chang, Ming‐Yang, Ong, Albert C. M. |
| المصدر: |
British Journal of Clinical Pharmacology; Oct2013, Vol. 76 Issue 4, p524-535, 12p |
| مصطلحات موضوعية: |
POLYCYSTIC kidney disease, CREB protein, MTOR inhibitors, THERAPEUTICS, VASOPRESSIN, CELL proliferation |
| مستخلص: |
Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited kidney disease and results from mutations in PKD1 or PKD2. Cyst initiation and expansion arise from a combination of abnormal cell proliferation, fluid secretion and extracellular matrix defects and results in kidney enlargement and interstitial fibrosis. Since its first description over 200 years ago, ADPKD has been considered an untreatable condition and its management is limited to blood pressure reduction and symptomatic treatment of disease complications. Results of the recently reported TEMPO 3/4 trial thus represent a paradigm shift in demonstrating for the first time that cystic disease and loss of renal function can be slowed in humans. In this paper, we review the major therapeutic strategies currently being explored in ADPKD including a range of novel approaches in preclinical models. It is anticipated that the clinical management of ADPKD will undergo a revolution in the next decade with the translation of new treatments into routine clinical use. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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