نتائج البحث

1

Target engagement and cellular fate of otelixizumab: a repeat dose escalation study of an anti‐CD3ε mAb in new‐onset type 1 diabetes mellitus patients

المؤلفون: Ruth M Barnard, David Inman, Kevin R. Page, Bart Keymeulen, Quentin Leirens, Alexander MacDonald, Antonella Napolitano, Kim Brown, David Lanham, Jonathan Bullman, Minesh Patel, André van Maurik, Enrica Mezzalana, Caroline O. S. Savage, Georgios Vlasakakis, Stefano Zamuner

المساهمون: Pathology/molecular and cellular medicine, Diabetes Pathology & Therapy, Diabetes Clinic

المصدر: British Journal of Clinical Pharmacology. 85:704-714

مصطلحات موضوعية: Adult, Male, Adolescent, CD3 Complex, type 1 diabetes, T-Lymphocytes, Receptors, Antigen, T-Cell, Pharmacology, Antibodies, Monoclonal, Humanized, 030226 pharmacology & pharmacy, Otelixizumab, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, medicine, immunoinflammation, Humans, Pharmacology (medical), Molecular Targeted Therapy, 030212 general & internal medicine, Dosing, Infusions, Intravenous, PK/PD models, Type 1 diabetes, Dose-Response Relationship, Drug, target engagement, business.industry, T-cell receptor, PK/PD, Original Articles, medicine.disease, Clinical trial, Diabetes Mellitus, Type 1, Treatment Outcome, Pharmacodynamics, Female, dose–response, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b3cc8aff306a4ae44c500abe35002d5Test
https://doi.org/10.1111/bcp.13842Test

2

The impact of liver transplant recipient and donor genetic variability on tacrolimus exposure and transplant outcome

المؤلفون: Jonathan Tuke, Alan Wigg, Libby John, Matthew P. Doogue, Jeyamani Ramachandran, Janet K. Coller

المصدر: Br J Clin Pharmacol

مصطلحات موضوعية: Adult, Graft Rejection, Male, medicine.medical_specialty, ATP Binding Cassette Transporter, Subfamily B, Genotyping Techniques, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, 030226 pharmacology & pharmacy, Gastroenterology, Tacrolimus, Nephrotoxicity, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Short Reports, Internal medicine, Genotype, otorhinolaryngologic diseases, Cytochrome P-450 CYP3A, Humans, Medicine, Pharmacology (medical), 030212 general & internal medicine, Genetic variability, CYP3A5, Aged, Retrospective Studies, Pharmacology, business.industry, Caspase 1, Haplotype, Australia, Middle Aged, Tissue Donors, Transplant Recipients, Liver Transplantation, Transplantation, surgical procedures, operative, Female, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bed875e7be05aa41b33bcca70626c69Test
https://doi.org/10.1111/bcp.14034Test

3

Perpetrator effects of ciclosporin (P‐glycoprotein inhibitor) and its combination with fluconazole (CYP3A inhibitor) on the pharmacokinetics of rivaroxaban in healthy volunteers

المؤلفون: Antonia Brings, David Czock, Marie-Louise Lehmann, Johanna Weiss, Kathrin I. Foerster, Walter E. Haefeli, Jürgen Burhenne

المصدر: Br J Clin Pharmacol

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::783ea078204f6e5fc775007b44906a4cTest
https://doi.org/10.1111/bcp.13934Test

4

Tenapanor administration and the activity of the H+‐coupled transporter PepT1 in healthy volunteers

المؤلفون: Johansson, Susanne, Rosenbaum, David P., Palm, Johan, Stefansson, Bergur, Knutsson, Mikael, Lisbon, Eleanor A., Hilgendorf, Constanze

المصدر: British Journal of Clinical Pharmacology

مصطلحات موضوعية: Adult, Male, Sulfonamides, Cross-Over Studies, Cefadroxil, PepT1, tenapanor, Middle Aged, Isoquinolines, Peptide Transporter 1, Healthy Volunteers, Anti-Bacterial Agents, Young Adult, Laxatives, sodium–hydrogen exchanger 3, Humans, Drug Interactions, Drug Therapy, Combination, Female

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::a5d8da11f75ca59ed6eff56ba4996869Test
http://europepmc.org/articles/PMC5582369Test

5

Effect of fermented red ginseng on cytochrome P450 and P‐glycoprotein activity in healthy subjects, as evaluated using the cocktail approach

المؤلفون: Ji-Young Jeon, Dal Sik Kim, Min-Gul Kim, Yunjeong Kim

المصدر: British Journal of Clinical Pharmacology
Br J Clin Pharmacol

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, cytochrome P450, Midazolam, Panax, Pharmacology, 030226 pharmacology & pharmacy, Losartan, Young Adult, 03 medical and health sciences, chemistry.chemical_compound, Ginseng, 0302 clinical medicine, Pharmacokinetics, Caffeine, Dextrorphan, medicine, P‐glycoprotein, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), Drug Interactions, ATP Binding Cassette Transporter, Subfamily B, Member 1, Letter to the Editor, Cytochrome P-450 CYP2C9, Paraxanthine, drug interaction, Cross-Over Studies, business.industry, CYP1A2, Area under the curve, food and beverages, Dextromethorphan, Middle Aged, Crossover study, Healthy Volunteers, 030104 developmental biology, Pharmaceutical Preparations, chemistry, Terfenadine, Fermented Foods, fermented red ginseng, business, Omeprazole, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::122dcde1b0eb6197daf9a55579c88488Test
http://europepmc.org/articles/PMC5099554Test

6

Edoxaban drug–drug interactions with ketoconazole, erythromycin, and cyclosporine

المؤلفون: Hamim Zahir, Dolly A. Parasrampuria, Nobuko Matsushima, Kenneth E. Truitt, Jeanne Mendell, Minggao Shi

المصدر: British Journal of Clinical Pharmacology

مصطلحات موضوعية: Adult, CYP3A4, medicine.drug_mechanism_of_action, Adolescent, Metabolic Clearance Rate, Pyridines, Factor Xa Inhibitor, Erythromycin, Administration, Oral, 030204 cardiovascular system & hematology, Pharmacology, Drug Administration Schedule, Substrate Specificity, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Pharmacokinetics, Edoxaban, P‐glycoprotein, Medicine, Cytochrome P-450 CYP3A, Humans, Pharmacology (medical), Drug Interactions, ATP Binding Cassette Transporter, Subfamily B, Member 1, Adverse effect, Cross-Over Studies, business.industry, Middle Aged, Healthy Volunteers, Thiazoles, Ketoconazole, chemistry, 030220 oncology & carcinogenesis, Pharmacodynamics, edoxaban, Cyclosporine, business, pharmacokinetics, medicine.drug, Factor Xa Inhibitors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::624c1e89477083ee92138c44969c8c38Test
http://europepmc.org/articles/PMC5099547Test

7

Impact of renal impairment and human organic anion transporter inhibition on pharmacokinetics, safety and tolerability of relebactam combined with imipenem and cilastatin

المؤلفون: Kenneth C. Lasseter, Francheska Colon-Gonzalez, Mallika Lala, Thomas Marbury, Matthew L. Rizk, Elizabeth G. Rhee, Joan R. Butterton, Patricia Jumes, Pratik Bhagunde, Shiyao Sherrie Xu, Yang Liu, Jin Wu, Graigory Garrett, Keith Boundy

المصدر: Br J Clin Pharmacol

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8efea3c6192c04ade5c364206b25b6aeTest
https://pubmed.ncbi.nlm.nih.gov/31856304Test

8

Fluid volume kinetics of 20% albumin

المؤلفون: Håkan Björne, Markus Zdolsek, Emma Hasselgren, Joachim Zdolsek, Robert G. Hahn

المصدر: Br J Clin Pharmacol

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f15498fc303fc4b1a42add01ed936d3Test
https://pubmed.ncbi.nlm.nih.gov/30756411Test

9

Pharmacokinetics of ixazomib, an oral proteasome inhibitor, in solid tumour patients with moderate or severe hepatic impairment

المؤلفون: Mark G. Qian, Gerald Steven Falchook, Neeraj Gupta, Robin E. Norris, Huyuan Yang, John Nemunaitis, Richard Labotka, Michael J. Hanley, Karthik Venkatakrishnan, Siqing Fu, Raymond P. Perez

المصدر: British Journal of Clinical Pharmacology

مصطلحات موضوعية: 0301 basic medicine, Adult, Boron Compounds, Male, medicine.medical_specialty, ixazomib, hepatic impairment, phase 1 clinical trial, Glycine, Phases of clinical research, Administration, Oral, Gastroenterology, Ixazomib, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, Pharmacokinetics, Internal medicine, Neoplasms, medicine, Humans, Pharmacology (medical), Adverse effect, solid tumours, Aged, Pharmacology, Aged, 80 and over, business.industry, proteasome inhibitor, Hepatic impairment, Liver Diseases, Middle Aged, Blood proteins, Confidence interval, Surgery, 030104 developmental biology, chemistry, 030220 oncology & carcinogenesis, Proteasome inhibitor, Female, business, Proteasome Inhibitors, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5db9f258ce89891d53fb094e7872859Test
http://europepmc.org/articles/PMC5089614Test

10

Exenatide acutely increases heart rate in parallel with augmented sympathetic nervous system activation in healthy overweight males

المصدر: British Journal of Clinical Pharmacology. 81(4):613-620

مصطلحات موضوعية: Adult, Blood Glucose, Male, Cross-Over Studies, Sympathetic Nervous System, Venoms, Overweight, Research Support, Lipids, Clinical Trial, Healthy Volunteers, Body Mass Index, Young Adult, SDG 3 - Good Health and Well-being, Glucagon-Like Peptide 1, Heart Rate, Journal Article, Humans, Vascular Resistance, Peptides, Non-U.S. Gov't

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=od______4612::2bc6ed35a94c91898626c8ef9b98fe4dTest
https://research.vu.nl/en/publications/d01119f2-9ac5-462a-ac26-cf15122c7b48Test

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