دورية أكاديمية
Natural immunity to SARS-CoV-2 and breakthrough infections in vaccinated and unvaccinated patients with cancer
| العنوان: | Natural immunity to SARS-CoV-2 and breakthrough infections in vaccinated and unvaccinated patients with cancer |
|---|---|
| المؤلفون: | Cortellini, Alessio, Aguilar-Company, Juan, Salazar, Ramon, Bower, Mark, Sita-Lumsden, Ailsa, Plaja, Andrea, Lee, Alvin JX, Bertuzzi, Alexia, Tondini, Carlo, Diamantis, Nikolaos, Martinez-Vila, Clara, Prat, Aleix, Apthorp, Eleanor, Gennari, Alessandra, Pinato, David J |
| المصدر: | British Journal of Cancer (2022) (In press). |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| المجموعة: | University College London: UCL Discovery |
| مصطلحات موضوعية: | Oncology, Public health |
| الوصف: | Background: Consolidated evidence suggests spontaneous immunity from SARS-CoV-2 is not durable, leading to the risk of reinfection, especially in the context of newly emerging viral strains. In patients with cancer who survive COVID-19 prevalence and severity of SARS-CoV-2 reinfections are unknown. / Methods: We aimed to document natural history and outcome from SARS-CoV-2 reinfection in patients recruited to OnCovid (NCT04393974), an active European registry enrolling consecutive patients with a history of solid or haematologic malignancy diagnosed with COVID-19. / Results: As of December 2021, out of 3108 eligible participants, 1806 COVID-19 survivors were subsequently followed at participating institutions. Among them, 34 reinfections (1.9%) were reported after a median time of 152 days (range: 40–620) from the first COVID-19 diagnosis, and with a median observation period from the second infection of 115 days (95% CI: 27–196). Most of the first infections were diagnosed in 2020 (27, 79.4%), while most of reinfections in 2021 (25, 73.5%). Haematological malignancies were the most frequent primary tumour (12, 35%). Compared to first infections, second infections had lower prevalence of COVID-19 symptoms (52.9% vs 91.2%, P = 0.0008) and required less COVID-19-specific therapy (11.8% vs 50%, P = 0.0013). Overall, 11 patients (32.4%) and 3 (8.8%) were fully and partially vaccinated against SARS-CoV-2 before the second infection, respectively. The 14-day case fatality rate was 11.8%, with four death events, none of which among fully vaccinated patients. / Conclusion: This study shows that reinfections in COVID-19 survivors with cancer are possible and more common in patients with haematological malignancies. Reinfections carry a 11% risk of mortality, which rises to 15% among unvaccinated patients, highlighting the importance of universal vaccination of patients with cancer. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | English |
| العلاقة: | https://discovery.ucl.ac.uk/id/eprint/10155073/1/Lee_Natural%20immunity%20to%20SARS-CoV-2%20and%20breakthrough%20infections%20in%20vaccinated%20and%20unvaccinated%20patients%20with%20cancer_AOP.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10155073Test/ |
| الإتاحة: | https://discovery.ucl.ac.uk/id/eprint/10155073/1/Lee_Natural%20immunity%20to%20SARS-CoV-2%20and%20breakthrough%20infections%20in%20vaccinated%20and%20unvaccinated%20patients%20with%20cancer_AOP.pdfTest https://discovery.ucl.ac.uk/id/eprint/10155073Test/ |
| حقوق: | open |
| رقم الانضمام: | edsbas.BCF7DC31 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |