التفاصيل البيبلوغرافية
| العنوان: |
Geographic clustering of testicular cancer incidence in the northern part of The Netherlands. |
| المؤلفون: |
Sonneveld, D J A, Schaapveld, M, Sleijfer, D Th, Meerman, G J Te, Graaf, W T A van der, Sijmons, R H, Koops, H Schraffordt, Hoekstra, H J |
| المصدر: |
British Journal of Cancer; 12/1/99, Vol. 81 Issue 7, p1262, 6p |
| مصطلحات موضوعية: |
SPERMATIC cord diseases, CANCER |
| مصطلحات جغرافية: |
NETHERLANDS |
| مستخلص: |
Geographic variations in testicular cancer incidence may be caused by differences in environmental factors, genetic factors, or both. In the present study, geographic patterns of age-adjusted testicular cancer incidence rates (IRs) in 12 provinces in The Netherlands in the period 1989-1995 were analysed. In addition, the age-adjusted IR of testicular cancer by degree of urbanization was evaluated. Cancer incidence data were obtained from the Netherlands Cancer Registry. The overall annual age-adjusted IR of testicular cancer in The Netherlands in the period 1989-1995 was 4.4 per 100 000 men. The province Groningen in the north of the country showed the highest annual IR with 5.8 per 100 000 men, which was higher (P < 0.05) than the overall IR in The Netherlands (incidence rate ratio (IRR) 1.3, 95% confidence interval (CI) 1.1-1.6). The highest IR in Groningen was seen for both seminomas and non-seminomas. In addition, Groningen showed the highest age-specific IRs in all relevant younger age groups (15-29, 30-44 and 45-59 years), illustrating the consistency of data. The province Friesland, also situated in the northern part of the country, showed the second highest IR of testicular cancer with 5.3 cases per 100 000 men per year (IRR 1.2, 95% CI 1.0-1.5, not significant). This mainly resulted from the high IR of seminoma in Friesland. Analysis of age-adjusted IRs of testicular cancer by degree of urbanization in The Netherlands showed no urban-rural differences at analysis of all histological types combined, or at separate analyses of seminomas and non-seminomas. Geographic clustering of testicular cancer seems to be present in the rural north of The Netherlands with some stable founder populations, which are likely to share a relatively high frequency of genes from common ancestors including genes possibly related to testicular cancer. Although this finding does not exclude the involvement of shared environmental factors in the aetiology of testicular cancer,... [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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