التفاصيل البيبلوغرافية
| العنوان: |
Oestrogen receptor pathway activity is associated with outcome in endometrial cancer. |
| المؤلفون: |
van Weelden, Willem Jan, van der Putten, Louis J. M., Inda, Márcia A., van Brussel, Anne, Snijders, Marc P. L. M., Schriever, Lisanne M. M., Bulten, Johan, Massuger, Leon F. A. G., van de Stolpe, Anja, Pijnenborg, Johanna M. A. |
| المصدر: |
British Journal of Cancer; Sep2020, Vol. 123 Issue 5, p785-792, 8p |
| مستخلص: |
Background: Oestrogen receptor (ER) expression is a prognostic biomarker in endometrial cancer (EC). However, expression does not provide information about the functional activity of the ER pathway. We evaluated a model to quantify ER pathway activity in EC, and determined the prognostic relevance of ER pathway activity.Methods: ER pathway activity was measured in two publicly available datasets with endometrial and EC tissue, and one clinical cohort with 107 samples from proliferative and hyperplastic endometrium and endometrioid-type EC (EEC) and uterine serous cancer (USC). ER pathway activity scores were inferred from ER target gene mRNA levels from Affymetrix microarray data (public datasets), or measured by qPCR on formalin-fixed paraffin-embedded samples (clinical cohort) and related to ER expression and outcome.Results: ER pathway activity scores differed significantly throughout the menstrual cycle supporting the validity of the pathway test. The highest ER pathway scores were found in proliferative and hyperplastic endometrium and stage I EEC, whereas stage II-IV EEC and USCs had significantly lower levels. Low ER pathway activity was associated with recurrent disease, and added prognostic value in patients with low ER expression.Conclusion: The ER pathway test reflects activity of the ER pathway, and may improve prediction of outcome in EC patients. [ABSTRACT FROM AUTHOR] |
|
Copyright of British Journal of Cancer is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder