Differential efficacy of flavone acetic against liver versus lung metastases in a human tumour xenograft
| العنوان: | Differential efficacy of flavone acetic against liver versus lung metastases in a human tumour xenograft |
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| المؤلفون: | F. Zunino, Riccardo A. Audisio, Monica Tortoreto, G Pratesi, Carla Manzotti |
| المصدر: | British Journal of Cancer |
| سنة النشر: | 1991 |
| مصطلحات موضوعية: | Cancer Research, Pathology, medicine.medical_specialty, Lung Neoplasms, Cell Survival, medicine.medical_treatment, Transplantation, Heterologous, Mice, Nude, Antineoplastic Agents, Biology, Metastasis, Mice, Liver Neoplasms, Experimental, Ovarian carcinoma, medicine, Carcinoma, Animals, Humans, Doxorubicin, Cisplatin, Flavonoids, Ovarian Neoplasms, Chemotherapy, Epithelioma, medicine.disease, Oncology, Cancer research, Female, Mitoflaxone, Cell Division, Neoplasm Transplantation, medicine.drug, Research Article |
| الوصف: | A human ovarian carcinoma, IGROV-1, was xenografted into different sites (i.p., s.c., i.v., and intrasplenically) in nude athymic female mice to investigate the pattern of antitumour efficacy of FAA and compare it to that of doxorubicin and cisplatin, two established cytotoxic drugs. Ascitic and lung-growing tumours totally failed to respond to FAA, whereas s.c. and liver-growing tumours were significantly growth inhibited. This pattern of activity differs from that achieved by the two conventional cytotoxic drugs, which were active against the IGROV-1 tumour growing in all of the tested sites. These studies indicate that cytotoxicity is not the major determinant of FAA antitumour efficacy even against human tumour xenografts. Moreover, the dramatic difference between the sensitivity of lung and liver tumour colonies demonstrates the great importance of the site of tumour growth for FAA efficacy. |
| اللغة: | English |
| تدمد: | 1532-1827 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd541b96da342d522e885c4831b754a5Test http://europepmc.org/articles/PMC1971638Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bd541b96da342d522e885c4831b754a5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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