Dietary exposure to polychlorinated biphenyls and risk of breast, endometrial and ovarian cancer in a prospective cohort
| العنوان: | Dietary exposure to polychlorinated biphenyls and risk of breast, endometrial and ovarian cancer in a prospective cohort |
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| المؤلفون: | Anders Glynn, Agneta Åkesson, Carolina Donat-Vargas, Maria Kippler, Marika Berglund, Alicja Wolk |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Epidemiology, polychlorinated biphenyls, Population, Breast Neoplasms, Food Contamination, 010501 environmental sciences, 01 natural sciences, 03 medical and health sciences, breast cancer, 0302 clinical medicine, Risk Factors, Surveys and Questionnaires, Internal medicine, medicine, Humans, Mammography, 030212 general & internal medicine, education, Prospective cohort study, Aged, 0105 earth and related environmental sciences, Ovarian Neoplasms, Sweden, prospective cohort study, education.field_of_study, medicine.diagnostic_test, business.industry, Endometrial cancer, environmental carcinogens, ovary cancer, Cancer, Environmental Exposure, Middle Aged, medicine.disease, endocrine disrupting chemicals, Diet, Endometrial Neoplasms, dietary exposure, Relative risk, endometrial cancer, Cohort, Female, Ovarian cancer, business |
| الوصف: | Background: Observational studies on polychlorinated biphenyl (PCB) exposure and hormone-related cancer risk are either inconsistent or lacking. We aimed to assess associations of dietary PCB exposure with breast, endometrial and ovarian cancer risk in middle-aged and elderly women. Methods: We included 36 777 cancer-free women at baseline in 1997 from the prospective population-based Swedish Mammography Cohort. Validated estimates of dietary PCB exposure were obtained via a food frequency questionnaire. Incident cancer cases were ascertained through register linkage. Results: During 14 years of follow-up, we ascertained 1593, 437 and 195 incident cases of breast, endometrial and ovarian cancer. We found no overall association between dietary PCB exposure and any of these cancer forms. The multivariable-adjusted relative risks comparing women in the highest and lowest tertile of PCB exposure were 0.96 (95% confidence interval (CI): 0.75, 1.24), 1.21 (95% CI: 0.73, 2.01) and 0.90 (95% CI: 0.45, 1.79) for breast, endometrial and ovarian cancer. In analyses stratified by factors influencing oestrogen exposure, possibly masking associations with PCBs, indications of higher risks were observed for endometrial cancer. Conclusions: This study suggests that dietary exposure to PCBs play no critical role in the development of breast, endometrial or ovarian cancer during middle-age and old ages. |
| تدمد: | 1532-1827 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3da9bec653b9a865f65287e2329fb5a3Test https://doi.org/10.1038/bjc.2016.282Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3da9bec653b9a865f65287e2329fb5a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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