التفاصيل البيبلوغرافية
| العنوان: |
Matrilysin (MMP-7) as a significant determinant of malignant potential of early invasive colorectal carcinomas |
| المؤلفون: |
Tadahiko Masaki, N. Abe, Akiteru Goto, Atsuhiko Sakamoto, Masanori Sugiyama, Hiroyoshi Matsuoka, Yutaka Atomi |
| المصدر: |
British Journal of Cancer |
| سنة النشر: |
2001 |
| مصطلحات موضوعية: |
Male, Cancer Research, Lymphatic metastasis, Pathology, medicine.medical_specialty, Rectum, budding, Biology, Matrix metalloproteinase, Metastasis, colorectal carcinoma, Carcinoma, medicine, Humans, metastasis, Neoplasm Invasiveness, Matrilysin, Neoplasm Metastasis, Aged, Retrospective Studies, Analysis of Variance, Rectal Neoplasms, matrilysin, Regular Article, Middle Aged, medicine.disease, Immunohistochemistry, medicine.anatomical_structure, Treatment Outcome, Oncology, Lymphatic Metastasis, Matrix Metalloproteinase 7, Colonic Neoplasms, Cancer research, Female, Neoplasm Recurrence, Local, Colorectal Neoplasms, Rectal disease, tumour invasion |
| الوصف: |
Matrix metalloproteinases play a crucial role in tumour invasion and mestasis. Matrilysin (MMP-7) has been shown to correlate with nodal or distant metastasis in colorectal carcinomas; however, its implication in early invasive colorectal carcinomas has not been determined. This study was undertaken to clarify the association of matrilysin expression with clinicopathologic parameters in early invasive colorectal carcinomas. 38 early invasive colorectal carcinomas treated by local excision or radical surgery were examined. Tumour budding was evaluated as the number of dedifferentiation units along the entire invasive margin. Matrilysin protein levels were determined using immunohistochemical study. Univariate analysis showed that matrilysin expression alone was significantly associated with distant metastasis (P= 0.0339), and both tumour budding and matrilysin expression were significantly associated with adverse outcome (P= 0.0005, 0.0341). Histological differentiation, vessel invasion, and depth of invasion were not significantly associated with either distant metastasis or adverse outcome. Multivariate analysis confirmed that tumour budding and matrilysin expression were independently associated with adverse outcome, although the significance of matrilysin expression was marginal (P= 0.0488). Tumour budding at the invasive margin and matrilysin expression are more useful in identifying high-risk groups for adverse outcome in patients with early invasive colorectal carcinomas. © 2001 Cancer Research Campaign www.bjcancer.com |
| تدمد: |
0007-0920 |
| الوصول الحر: |
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e2a991af7db2322c22f72744902a904Test
https://pubmed.ncbi.nlm.nih.gov/11355941Test |
| حقوق: |
OPEN |
| رقم الانضمام: |
edsair.doi.dedup.....6e2a991af7db2322c22f72744902a904 |
| قاعدة البيانات: |
OpenAIRE |
