Biomarkers and outcome after tamoxifen treatment in node-positive breast cancers from elderly women
| العنوان: | Biomarkers and outcome after tamoxifen treatment in node-positive breast cancers from elderly women |
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| المؤلفون: | E. Benini, Gabriele Martelli, Maria Grazia Daidone, Rosella Silvestrini, Gorana Tomasic, G. De Palo, Silvia Veneroni, A Luisi |
| المصدر: | British Journal of Cancer Scopus-Elsevier |
| سنة النشر: | 2000 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Pathology, Aging, Antineoplastic Agents, Hormonal, p53 expression, medicine.medical_treatment, Mammary gland, hormone responsiveness, Breast Neoplasms, Biology, elderly patients, Metastasis, Predictive Value of Tests, Internal medicine, medicine, Biomarkers, Tumor, Humans, Prospective Studies, Prospective cohort study, Lymph node, Aged, Aged, 80 and over, Chemotherapy, oestrogen receptors, Hazard ratio, Regular Article, Antiestrogen, medicine.disease, Genes, p53, Prognosis, Genes, bcl-2, Radiation therapy, Gene Expression Regulation, Neoplastic, Tamoxifen, medicine.anatomical_structure, Treatment Outcome, cell proliferation, Receptors, Estrogen, bcl-2 expression, Female, Cell Division |
| الوصف: | The predictive role of tumour proliferative rate and expression of p53, bcl-2 and bax proteins, alone and in association with tumour size, nodal involvement and oestrogen receptors (ER), was analysed on 145 elderly patients (≥70 years of age) with histologically assessed node-positive breast cancers treated with radical or conservative surgery plus radiotherapy followed by adjuvant tamoxifen for at least 1 year. The 7-year probability of relapse was significantly higher for patients with tumours rapidly proliferating (hazard ratio (HR) = 2.0, P = 0.01), overexpressing p53 (HR = 4.4, P = 0.0001), weakly or not exhibiting bcl-2 (HR = 1.9, P = 0.02), without ERs (HR = 3.4, P = 0.0001) or with ≥ 4 positive lymph nodes (HR = 2.3, P = 0.003) than for patients with tumours expressing the opposite patho-biological profile. Conversely, tumour size and bax expression failed to influence relapse-free survival. Adjustment for the duration of tamoxifen treatment did not change these findings. Oestrogen receptors, cell proliferation, p53 accumulation and bcl-2 expression were also predictive for overall survival. Within ER-positive tumours, cell proliferation, p53 accumulation, bcl-2 expression and lymph node involvement provided significant and independent information for relapse and, in association, identified subgroups of patients with relapse probabilities of 20% (low-risk group, exhibiting only one unfavourable factor) to 90% (high-risk group, exhibiting three unfavourable factors). Such data could represent the initial framework for a biologically tailored therapy even for elderly patients and highlight the importance of a patho-biological characterization of their breast cancers. © 2000 Cancer Research Campaign |
| تدمد: | 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5076692804acfb32bc1017debec0d7f0Test https://pubmed.ncbi.nlm.nih.gov/10646876Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5076692804acfb32bc1017debec0d7f0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00070920 |
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