Long-term follow-up of elderly patients with operable breast cancer treated with surgery without axillary dissection plus adjuvant tamoxifen
| العنوان: | Long-term follow-up of elderly patients with operable breast cancer treated with surgery without axillary dissection plus adjuvant tamoxifen |
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| المؤلفون: | G. Depalo, Gaetano Vetrella, Gabriele Martelli, Nicoletta Rossi, Patrizia Boracchi, E Galante, Danila Coradini |
| المصدر: | British Journal of Cancer Scopus-Elsevier |
| بيانات النشر: | Springer Science and Business Media LLC, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Antineoplastic Agents, Hormonal, Breast Neoplasms, Breast cancer, Humans, Medicine, Life Tables, Survival rate, Aged, Retrospective Studies, Aged, 80 and over, business.industry, Carcinoma, Estrogen Antagonists, Cancer, medicine.disease, Antiestrogen, Combined Modality Therapy, Neoplasm Proteins, Surgery, Survival Rate, Tamoxifen, Axilla, Treatment Outcome, medicine.anatomical_structure, Receptors, Estrogen, Oncology, Chemotherapy, Adjuvant, Concomitant, Hormonal therapy, Female, Lymph Nodes, Receptors, Progesterone, business, Research Article, Follow-Up Studies, medicine.drug |
| الوصف: | Between 1982 and 1990, 321 elderly patients (range 70-92 years, median age 77) with operable breast cancer (T1 in 219, T2 in 77, T3 in one and T4b in 24 patients) and clinically uninvolved axillary nodes underwent surgery without axillary dissection and received adjuvant tamoxifen. All patients had surgery performed under local anaesthesia. Tamoxifen was given after surgery at the dose of 20 mg daily, indefinitely. With a median follow-up of 67 months (range 42-141), 17 patients developed local relapse, 14 ipsilateral axillary recurrence, five ipsilateral breast cancer, five contralateral breast cancer, 13 second primary and 23 developed distant metastases. The cumulative probability of developing a local, axillary and distant recurrence at 72 months was estimated to be 5.4%, 4.3% and 6.2%, respectively. Out of 244 patients who did not develop any relapse, 83 (25.8%) died from intercurrent disease. The 72 month relapse-free survival rate was 76%. This experience suggests that elderly patients with small tumours without clinical axillary involvement may be satisfactorily treated with conservative surgery and tamoxifen. The importance of axillary dissection is controversial owing to a high response rate to hormonal therapy and an increased death rate due to concomitant diseases. |
| تدمد: | 1532-1827 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a70e345075608c885d37216f81993afTest https://doi.org/10.1038/bjc.1995.495Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6a70e345075608c885d37216f81993af |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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