Prognostic relevance of the mitotic count and the amount of viable tumour after neoadjuvant chemotherapy for primary, localised, high-grade soft tissue sarcoma
| العنوان: | Prognostic relevance of the mitotic count and the amount of viable tumour after neoadjuvant chemotherapy for primary, localised, high-grade soft tissue sarcoma |
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| المؤلفون: | Mathias Werner, Markus K. Schuler, Daniel Pink, Frank Traub, Dimosthenis Andreou, Georg Gosheger, Björn Jobke, Peter Reichardt, Per-Ulf Tunn |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Male, neoadjuvant treatment, Oncology, Cancer Research, medicine.medical_specialty, Neoplasm, Residual, Mitotic index, Adolescent, Anthracycline, Cell Survival, medicine.medical_treatment, Antineoplastic Agents, Soft Tissue Neoplasms, Gastroenterology, Disease-Free Survival, Young Adult, viable tumour, Predictive Value of Tests, Internal medicine, Mitotic Index, medicine, Humans, Anthracyclines, mitotic count, Antineoplastic Agents, Alkylating, Neoadjuvant therapy, Aged, Retrospective Studies, response assessment, Chemotherapy, business.industry, Soft tissue sarcoma, Sarcoma, Retrospective cohort study, Middle Aged, Prognosis, medicine.disease, Neoadjuvant Therapy, soft tissue sarcoma, Predictive value of tests, Clinical Study, Female, Neoplasm Grading, business |
| الوصف: | Background: We sought to examine whether mitotic count (MC) and the amount of viable tumour (VT) following neoadjuvant systemic chemotherapy (SC) for primary, localised, high-grade soft tissue sarcoma (STS) correlate with prognosis. Methods: Retrospective analysis of 57 patients who underwent SC involving a combination of an anthracycline and an alkylating agent, followed by surgical resection between 2001 and 2011. Results: The amount of VT after chemotherapy was significantly associated with disease-specific survival (DSS) and event-free survival (EFS). Patients with |
| تدمد: | 1532-1827 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd02a68d6dd50b0fbbc53a43c0ccdb9aTest https://doi.org/10.1038/bjc.2014.635Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bd02a68d6dd50b0fbbc53a43c0ccdb9a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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