The ProtecT randomised trial cost-effectiveness analysis comparing active monitoring, surgery, or radiotherapy for prostate cancer
| العنوان: | The ProtecT randomised trial cost-effectiveness analysis comparing active monitoring, surgery, or radiotherapy for prostate cancer |
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| المؤلفون: | Jon Oxley, Malcolm David Mason, Alan Paul, Howard Kynaston, Richard M. Martin, J. Athene Lane, Chris Metcalfe, Vincent J. Gnanapragasam, Emma L Turner, Prasad Bollina, Derek J. Rosario, Owen Hughes, James W.F. Catto, David E. Neal, Sian Noble, Alan Doherty, Joanna Thorn, John Staffurth, Kirsty Garfield, Edgar Paez, Jenny L Donovan, Tim J Peters, Edward Rowe, Roger Kockelbergh, Eleanor I Walsh, Michael Davis, Freddie C. Hamdy |
| المساهمون: | Noble, Sian M [0000-0002-8011-0722], Apollo - University of Cambridge Repository, Noble, Sian M. [0000-0002-8011-0722] |
| المصدر: | British Journal of Cancer Noble, S M, Garfield, K, Lane, J A, Metcalfe, C, Davis, M, Walsh, E I, Martin, R M, Turner, E L, Peters, T J, Thorn, J C, Mason, M, Bollina, P, Catto, J, Doherty, A, Gnanapragasam, V, Hughes, O, Kockelbergh, R, Kynaston, H, Paul, A, Paez, E, Rosario, D J, Rowe, E, Oxley, J, Staffurth, J, Neal, D, Hamdy, F C & Donovan, J L 2020, ' The ProtecT randomised trial cost-effectiveness analysis comparing Active Monitoring, Surgery, or Radiotherapy for Prostate Cancer ', British Journal of Cancer . https://doi.org/10.1038/s41416-020-0978-4Test |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, Cancer Research, medicine.medical_specialty, medicine.medical_treatment, Cost-Benefit Analysis, Nice, BTC (Bristol Trials Centre), Article, law.invention, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Randomized controlled trial, law, Prostate, medicine, HEB, Humans, 692/700/3934, 030212 general & internal medicine, health care economics and organizations, computer.programming_language, Aged, business.industry, Cancer, Prostatic Neoplasms, Cost-effectiveness analysis, Health Care Costs, Middle Aged, Health care economics, medicine.disease, Quality-adjusted life year, Surgery, Radiation therapy, medicine.anatomical_structure, Oncology, 692/4028/67/589/466, 030220 oncology & carcinogenesis, BRTC, ICEP, Quality-Adjusted Life Years, business, computer |
| الوصف: | Background There is limited evidence relating to the cost-effectiveness of treatments for localised prostate cancer. Methods The cost-effectiveness of active monitoring, surgery, and radiotherapy was evaluated within the Prostate Testing for Cancer and Treatment (ProtecT) randomised controlled trial from a UK NHS perspective at 10 years’ median follow-up. Prostate cancer resource-use collected from hospital records and trial participants was valued using UK reference-costs. QALYs (quality-adjusted-life-years) were calculated from patient-reported EQ-5D-3L measurements. Adjusted mean costs, QALYs, and incremental cost-effectiveness ratios were calculated; cost-effectiveness acceptability curves and sensitivity analyses addressed uncertainty; subgroup analyses considered age and disease-risk. Results Adjusted mean QALYs were similar between groups: 6.89 (active monitoring), 7.09 (radiotherapy), and 6.91 (surgery). Active monitoring had lower adjusted mean costs (£5913) than radiotherapy (£7361) and surgery (£7519). Radiotherapy was the most likely (58% probability) cost-effective option at the UK NICE willingness-to-pay threshold (£20,000 per QALY). Subgroup analyses confirmed radiotherapy was cost-effective for older men and intermediate/high-risk disease groups; active monitoring was more likely to be the cost-effective option for younger men and low-risk groups. Conclusions Longer follow-up and modelling are required to determine the most cost-effective treatment for localised prostate cancer over a man’s lifetime. Trial registration Current Controlled Trials number, ISRCTN20141297: http://isrctn.orgTest (14/10/2002); ClinicalTrials.gov number, NCT02044172: http://www.clinicaltrials.govTest (23/01/2014). |
| وصف الملف: | application/pdf; application/zip; text/xml |
| تدمد: | 1532-1827 2014-1297 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9aa5ff9ad5b35748d53f22dcb414e6eTest https://pubmed.ncbi.nlm.nih.gov/32669672Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c9aa5ff9ad5b35748d53f22dcb414e6e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 20141297 00070920 |
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