Feasibility RCT of definitive chemoradiotherapy or chemotherapy and surgery for oesophageal squamous cell cancer
| العنوان: | Feasibility RCT of definitive chemoradiotherapy or chemotherapy and surgery for oesophageal squamous cell cancer |
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| المؤلفون: | Jenny L Donovan, William Hollingworth, Caroline Wilson, Christopher Streets, S. M. Griffin, Tom Crosby, Dan Titcomb, Jane M Blazeby, R. Krysztopik, Sean Strong, CP Barham, Sara T Brookes, Stephen Falk, James L. Nicklin, A D Hollowood |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, oesophageal cancer, Cancer Research, medicine.medical_specialty, Esophageal Neoplasms, medicine.medical_treatment, Pilot Projects, Deoxycytidine, pilot RCT, surgery, Capecitabine, chemistry.chemical_compound, Antineoplastic Combined Chemotherapy Protocols, medicine, Carcinoma, Humans, Neoadjuvant therapy, Cisplatin, Chemotherapy, business.industry, Chemoradiotherapy, medicine.disease, Neoadjuvant Therapy, Surgery, stomatognathic diseases, Treatment Outcome, Oncology, chemistry, Fluorouracil, Carcinoma, Squamous Cell, Clinical Study, Feasibility Studies, Female, Esophageal Squamous Cell Carcinoma, business, human activities, qualitative methods, medicine.drug |
| الوصف: | Background: The optimal treatment for localised oesophageal squamous cell carcinoma (SCC) is uncertain. We assessed the feasibility of an RCT comparing neoadjuvant treatment and surgery with definitive chemoradiotherapy. Methods: A feasibility RCT in three centres examined incident patients and reasons for ineligibility using multi-disciplinary team meeting records. Eligible patients were offered participation in the RCT with integrated qualitative research involving audio-recorded recruitment appointments and interviews with patients to inform recruitment training for staff. Results: Of 375 patients with oesophageal SCC, 42 (11.2%) were eligible. Reasons for eligibility varied between centres, with significantly differing proportions of patients excluded because of total tumour length (P=0.002). Analyses of audio-recordings and patient interviews showed that recruiters had challenges articulating the trial design in simple terms, balancing treatment arms and explaining the need for randomisation. Before analyses of the qualitative data and recruiter training no patients were randomised. Following training in one centre 5 of 16 eligible patients were randomised. Conclusions: An RCT of surgical vs non-surgical treatment for SCC of the oesophagus is not feasible in the UK alone because of the low number of incident eligible patients. A trial comparing diverse treatment approaches may be possible with investment to support the recruitment process. |
| تدمد: | 1532-1827 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::951362eaf8f8451ce05aa3c33d978743Test https://doi.org/10.1038/bjc.2014.313Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....951362eaf8f8451ce05aa3c33d978743 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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