Integrative pharmacological mechanism of vitamin C combined with glycyrrhizic acid against COVID-19: findings of bioinformatics analyses
| العنوان: | Integrative pharmacological mechanism of vitamin C combined with glycyrrhizic acid against COVID-19: findings of bioinformatics analyses |
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| المؤلفون: | Yu Li, Xiao Liang, Jian Chen, Ka Wu, Rong Li, Keng Po Lai |
| المصدر: | Briefings in Bioinformatics |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | bioinformatics analysis, ERBB signaling pathway, AcademicSubjects/SCI01060, vitamin C, Ascorbic Acid, Bioinformatics, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immunity, Humans, Medicine, KEGG, Molecular Biology, 030304 developmental biology, 0303 health sciences, Case Study, biotarget, business.industry, Mechanism (biology), COVID-19, Computational Biology, Ascorbic acid, COVID-19 Drug Treatment, Clinical trial, Vascular endothelial growth factor, chemistry, 030220 oncology & carcinogenesis, glycyrrhizic acid, Drug Therapy, Combination, Signal transduction, business, Information Systems |
| الوصف: | ObjectiveCoronavirus disease 2019 (COVID-19) is a fatal and fast-spreading viral infection. To date, the number of COVID-19 patients worldwide has crossed over six million with over three hundred and seventy thousand deaths (according to the data from World Health Organization; updated on 2 June 2020). Although COVID-19 can be rapidly diagnosed, efficient clinical treatment of COVID-19 remains unavailable, resulting in high fatality. Some clinical trials have identified vitamin C (VC) as a potent compound pneumonia management. In addition, glycyrrhizic acid (GA) is clinically as an anti-inflammatory medicine against pneumonia-induced inflammatory stress. We hypothesized that the combination of VC and GA is a potential option for treating COVID-19.MethodsThe aim of this study was to determine pharmacological targets and molecular mechanisms of VC + GA treatment for COVID-19, using bioinformational network pharmacology.ResultsWe uncovered optimal targets, biological processes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of VC + GA against COVID-19. Our findings suggested that combinatorial VC and GA treatment for COVID-19 was associated with elevation of immunity and suppression of inflammatory stress, including activation of the T cell receptor signaling pathway, regulation of Fc gamma R-mediated phagocytosis, ErbB signaling pathway and vascular endothelial growth factor signaling pathway. We also identified 17 core targets of VC + GA, which suggest as antimicrobial function.ConclusionsFor the first time, our study uncovered the pharmacological mechanism underlying combined VC and GA treatment for COVID-19. These results should benefit efforts to address the most pressing problem currently facing the world. |
| اللغة: | English |
| تدمد: | 1477-4054 1467-5463 |
| DOI: | 10.1093/bib/bbaa141 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9e50d9a1d9b3562e8a909d954020205Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c9e50d9a1d9b3562e8a909d954020205 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14774054 14675463 |
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| DOI: | 10.1093/bib/bbaa141 |