Are We Ready to Use ESR1 Mutations in Clinical Practice
| العنوان: | Are We Ready to Use ESR1 Mutations in Clinical Practice |
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| المؤلفون: | Rinath Jeselsohn |
| المصدر: | Breast Care. 12:309-313 |
| بيانات النشر: | S. Karger AG, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.drug_class, Estrogen receptor, Review Article, 03 medical and health sciences, 0302 clinical medicine, Medicine, Aromatase, biology, Fulvestrant, business.industry, medicine.disease, Metastatic breast cancer, body regions, Clinical trial, 030104 developmental biology, Oncology, Estrogen, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Surgery, business, Estrogen receptor alpha, Tamoxifen, medicine.drug |
| الوصف: | The recurrent ligand-binding domain ESR1 mutations are an important mechanism of endocrine resistance in estrogen receptor-positive (ER+) metastatic breast cancer. These mutations evolve under the selective pressure of endocrine treatments and are rarely found in treatment-naïve ER+ breast cancers. Preclinical studies showed that these mutations lead to ligand-independent activity facilitating resistance to aromatase inhibitors and relative resistance to tamoxifen and fulvestrant. Retrospective analyses of ESR1 mutations in baseline plasma circulating tumor DNA from clinical trials suggest that these mutations are prognostic of poor overall survival and predictive of resistance to aromatase inhibitors in metastatic disease. Larger datasets and prospective studies to confirm these results are lacking. In addition, response to other standard treatments for metastatic breast cancer in the presence of the ESR1 mutations is unknown, and studies to determine the optimal treatment combinations for patients with ESR1 mutations are also needed. |
| تدمد: | 1661-3805 1661-3791 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c30b1b324f668483a8057a0dace9f7dTest https://doi.org/10.1159/000481428Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5c30b1b324f668483a8057a0dace9f7d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16613805 16613791 |
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