Pure anti-tumor effect of zoledronic acid in naïve bone-only metastatic and locally advanced breast cancer: proof from the 'biological window therapy'
| العنوان: | Pure anti-tumor effect of zoledronic acid in naïve bone-only metastatic and locally advanced breast cancer: proof from the 'biological window therapy' |
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| المؤلفون: | Elena A Takano, Giulia Brugnoli, Manuela Milan, Laura B Pritzker, Daniele Santini, Sergio Venturini, Alberto Bottini, Carla Strina, Mara Bonelli, Daniele Generali, Claudia Fumarola, Chiara Foroni, Pier Giorgio Petronini, Vanessa Zanoni, Ramona Bertoni, Mariarosa Cappelletti, Giuseppina Ferrero, Mara Maldotti, Amadeo M. Parissenti, Stephen B. Fox, Daniele Andreis, Kenneth P.H. Pritzker |
| المساهمون: | Foroni, Chiara, Milan, Manuela, Strina, Carla, Cappelletti, Mariarosa, Fumarola, Claudia, Bonelli, Mara, Bertoni, Ramona, Ferrero, Giuseppina, Maldotti, Mara, Takano, Elena, Andreis, Daniele, Venturini, Sergio, Brugnoli, Giulia, Petronini, Pier Giorgio, Zanoni, Vanessa, Pritzker, Laura, Pritzker, Kenneth, Parissenti, Amadeo, Santini, Daniele, Fox, Stephen B., Bottini, Alberto, Generali, Daniele |
| المصدر: | Breast Cancer Research and Treatment. 144:113-121 |
| بيانات النشر: | Springer Science and Business Media LLC, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Oncology, BREAST CANCER, CIRCULATING TUMOR CELLS, KI67, WINDOW THERAPY, ZOLEDRONIC ACID, ADULT, AGED, 80 AND OVER, BONE DENSITY CONSERVATION AGENTS, BONE NEOPLASMS, BREAST NEOPLASMS, DIPHOSPHONATES, FEMALE, HUMANS, IMIDAZOLES, IMMUNOHISTOCHEMISTRY, MIDDLE AGED, NEOPLASTIC CELLS, CIRCULATING, ONCOLOGY, CANCER RESEARCH, Cancer Research, Pathology, CD34, Neoplastic Cells, Basal (phylogenetics), Breast cancer, Circulating tumor cell, Window therapy, 80 and over, Circulating, Aged, 80 and over, Bone Density Conservation Agents, Diphosphonates, BREAST CANCER, CIRCULATING TUMOR CELLS, KI67, WINDOW THERAPY, ZOLEDRONIC ACID, ADULT, AGED, AGED, 80 AND OVER, BONE DENSITY CONSERVATION AGENTS, BONE NEOPLASMS, BREAST NEOPLASMS, DIPHOSPHONATES, FEMALE, HUMANS, IMIDAZOLES, IMMUNOHISTOCHEMISTRY, MIDDLE AGED, NEOPLASTIC CELLS, CIRCULATING, ONCOLOGY, CANCER RESEARCH, Imidazoles, Bone metastasis, Middle Aged, Neoplastic Cells, Circulating, Immunohistochemistry, Diphosphonate, Settore SECS-S/01 - STATISTICA, Female, Ki67, Breast Neoplasm, Human, medicine.drug, Adult, medicine.medical_specialty, Bone Density Conservation Agent, Bone Neoplasms, Breast Neoplasms, Bone Neoplasm, Circulating tumor cells, Zoledronic acid, Aged, Humans, In vivo, Internal medicine, medicine, Imidazole, business.industry, medicine.disease, Apoptosis, business |
| الوصف: | The study investigated the anti-tumour effect of zoledronic acid (ZA) administered alone in a biological window therapy in naïve bone-only metastatic and locally advanced breast cancer (LABC) patients. 33 patients with LABC (Group 1) and 20 patients with a first diagnosis of bone metastasis only (Group 2) received 4 mg single dose of ZA, 14 days (biological window) before starting any treatment. In Group 1, Ki67, CD34, p53/bcl-2 and caspase 3 expression along with the adenosine triphosphate (ATP) levels and RNA disruption index were evaluated as markers of tumor growth in tumour specimens obtained before and after ZA administration (basal, day 14). In Group 2, the total enumeration of circulating tumour cells (CTCs), and of M30+ve CTCs along with the soluble marker of cell death (M30/M65) were carried-out as markers of tumor dissemination at baseline, at 48 h and day 14th. In Group 1, there was a significant reduction in Ki67, CD34, bcl-2 expression after 14 days ZA based-treatment (p = 0.0032; p = 0.0001, p < 0.00001 respectively). ZA showed a significant increase of RNA disruption (p < 0.0076). In Group 2, we observed a significant reduction of CTCs number after 48 h (p = 0.0012), followed by a significant rebound at 14 days (p = 0.012). The apoptotic CTCs/M30+ve and M65 levels significantly increased under treatment (p = 0.018 and p = 0.039 respectively) after drug administration when compared to the baseline. These results are the first prospective in vivo data showing the direct pure anti-tumour effect (either on the tumour cell or on CTCs) of ZA. |
| وصف الملف: | ELETTRONICO |
| تدمد: | 1573-7217 0167-6806 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc28fee3cc89969b86973cd26a726b4Test https://doi.org/10.1007/s10549-014-2840-yTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0fc28fee3cc89969b86973cd26a726b4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15737217 01676806 |
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