Involvement of calcium in pain and antinociception
| العنوان: | Involvement of calcium in pain and antinociception |
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| المؤلفون: | Wiliam A. Prado |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 34, Iss 4, Pp 449-461 (2001) Brazilian Journal of Medical and Biological Research, Volume: 34, Issue: 4, Pages: 449-461, Published: APR 2001 Brazilian Journal of Medical and Biological Research v.34 n.4 2001 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Cytoplasmic calcium, Physiology, Immunology, Clinical pain, Cell, Analgesic, Biophysics, chemistry.chemical_element, Pain, Pharmacology, Calcium, Biochemistry, Cell membrane, chemistry.chemical_compound, Mice, calcium antagonists, medicine, Animals, Humans, General Pharmacology, Toxicology and Pharmaceutics, Neurotransmitter, lcsh:QH301-705.5, antinociception, Pain Measurement, calcium ions, lcsh:R5-920, General Neuroscience, Nociceptors, opioids, analgesia, Cell Biology, General Medicine, Calcium Channel Blockers, Rats, Analgesics, Opioid, Nociception, medicine.anatomical_structure, chemistry, lcsh:Biology (General), Calcium Channels, lcsh:Medicine (General) |
| الوصف: | Calcium ions are widely recognized to play a fundamental role in the regulation of several biological processes. Transient changes in cytoplasmic calcium ion concentration represent a key step for neurotransmitter release and the modulation of cell membrane excitability. Evidence has accumulated for the involvement of calcium ions also in nociception and antinociception, including the analgesic effects produced by opioids. The combination of opioids with drugs able to interfere with calcium ion functions in neurons has been pointed out as a useful alternative for safer clinical pain management. Alternatively, drugs that reduce the flux of calcium ions into neurons have been indicated as analgesic alternatives to opioids. This article reviews the manners by which calcium ions penetrate cell membranes and the changes in these mechanisms caused by opioids and calcium antagonists regarding nociceptive and antinociceptive events. |
| وصف الملف: | text/html |
| اللغة: | English |
| تدمد: | 0034-7310 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea6857a80c36ee7fb7eb253a28646a15Test http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2001000400003Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....ea6857a80c36ee7fb7eb253a28646a15 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00347310 |
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