Predictors of early treatment discontinuation and severe anemia in a Brazilian cohort of hepatitis C patients treated with first-generation protease inhibitors
| العنوان: | Predictors of early treatment discontinuation and severe anemia in a Brazilian cohort of hepatitis C patients treated with first-generation protease inhibitors |
|---|---|
| المؤلفون: | L.P. Zanaga, L.C. Mendes, Eduardo S L Gonçales, Marcelo N. Pedro, M.S.K. Lazarini, A.G. Vigani, Fernando L. Gonçales, Raquel Silveira Bello Stucchi, Noelle Miotto |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 49, Iss 7 (2016) Brazilian Journal of Medical and Biological Research Brazilian Journal of Medical and Biological Research v.49 n.7 2016 Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Volume: 49, Issue: 7, Article number: e5300, Published: 23 JUN 2016 |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Male, Medicine (General), Time Factors, Sustained Virologic Response, Physiology, Severity of Illness Index, Biochemistry, Gastroenterology, Polyethylene Glycols, Telaprevir, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, Prospective Studies, Treatment Failure, 030212 general & internal medicine, General Pharmacology, Toxicology and Pharmaceutics, Biology (General), Prospective cohort study, lcsh:QH301-705.5, lcsh:R5-920, General Neuroscience, Anemia, General Medicine, Hepatitis C, Middle Aged, Recombinant Proteins, Female, 030211 gastroenterology & hepatology, lcsh:Medicine (General), Oligopeptides, Glomerular Filtration Rate, medicine.drug, Adult, medicine.medical_specialty, Proline, QH301-705.5, Immunology, Biophysics, Ocean Engineering, Treatment interruption, Antiviral Agents, Statistics, Nonparametric, Young Adult, 03 medical and health sciences, R5-920, Hepatitis C treatment, Internal medicine, Boceprevir, Ribavirin, medicine, Humans, Protease Inhibitors, Clinical Investigation, Adverse effect, Aged, business.industry, Interferon-alpha, Cell Biology, Hepatitis C, Chronic, medicine.disease, Discontinuation, Surgery, Logistic Models, lcsh:Biology (General), chemistry, Protease inhibitor, Adverse events, business |
| الوصف: | The aim of this study was to determine risk factors for adverse events (AE)-related treatment discontinuation and severe anemia among patients with chronic hepatitis C virus (HCV) genotype 1 infection, treated with first-generation protease inhibitor (PI)-based therapy. We included all patients who initiated treatment with PI-based therapy at a Brazilian university hospital between November 2013 and December 2014. We prospectively collected data from medical records using standardized questionnaires and used Epi Info 6.0 for analysis. Severe anemia was defined as hemoglobin ≤8.5 mg/dL. We included 203 patients: 132 treated with telaprevir (TVR) and 71 treated with boceprevir (BOC). AE-related treatment discontinuation rate was 19.2% and anemia was the main reason (38.5%). Risk factors for treatment discontinuation were higher comorbidity index (OR=1.85, CI=1.05-3.25) for BOC, and higher bilirubin count (OR=1.02, CI=1.01-1.04) and lower BMI (OR=0.98, CI=0.96-0.99) for TVR. Severe anemia occurred in 35 (17.2%) patients. Risk factors for this outcome were lower estimated glomerular filtration rate (eGFR; OR=0.95, CI=0.91-0.98) for patients treated with TVR, and higher comorbidity index (OR=2.21, CI=1.04-4.67) and ribavirin dosage (OR=0.84, CI=0.72-0.99) for those treated with BOC. Fifty-five (57.3%) patients treated with TVR and 15 (27.3%) patients treated with BOC achieved sustained virological response (SVR). Among patients who received TVR and interrupted treatment due to AE (n=19), only 26.3% (n=5) achieved SVR (P=0.003). Higher number of comorbidities, lower eGFR and advanced liver disease are associated with severe anemia and early treatment cessation, which may compromise SVR achievement. |
| وصف الملف: | text/html |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb2869cc8577607c096675069547a3dTest http://www.scielo.br/pdf/bjmbr/v49n7/1414-431X-bjmbr-1414-431X20165300.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7eb2869cc8577607c096675069547a3d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |