Short-term quality of life after subthalamic stimulation depends on non-motor symptoms in Parkinson's disease
| العنوان: | Short-term quality of life after subthalamic stimulation depends on non-motor symptoms in Parkinson's disease |
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| المؤلفون: | Lars Timmermann, Luisa Weiß, Haidar S. Dafsari, Veerle Visser-Vandewalle, K. Ray-Chaudhuri, Keyoumars Ashkan, Alexandra Rizos, Jan Niklas Petry-Schmelzer, Pablo Martinez-Martin, Angelo Antonini, Prashanth Reddy, Monty Silverdale, Michael Samuel, Julian Evans, Europar, Paul Reker |
| المصدر: | Dafsari, H S, Weiß, L, Silverdale, M, Rizos, A, Reddy, P, Ashkan, K, Evans, J, Reker, P, Petry-Schmelzer, J N, Samuel, M, Visser-Vandewalle, V, Antonini, A, Martinez-Martin, P, Ray-Chaudhuri, K & Timmermann, L 2018, ' Short-term quality of life after subthalamic stimulation depends on non-motor symptoms in Parkinson's disease ', Brain Stimulation . https://doi.org/10.1016/j.brs.2018.02.015Test Brain Stimulation, Vol 11, Iss 4, Pp 867-874 (2018) EUROPAR and the IPMDS (International Parkinson's and Movement Disorders Society) Non-Motor Parkinson's Disease Study Group 2018, ' Short-term quality of life after subthalamic stimulation depends on non-motor symptoms in Parkinson's disease ', Brain Stimulation, vol. 11, no. 4, pp. 867-874 . https://doi.org/10.1016/j.brs.2018.02.015Test |
| بيانات النشر: | Elsevier BV, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Quality of Life/psychology, Time Factors, Parkinson's disease, Activities of daily living, Deep Brain Stimulation, medicine.medical_treatment, Logistic regression, Subthalamic nucleus, 0302 clinical medicine, Quality of life, Activities of Daily Living, Deep brain stimulation, Prospective Studies, Registries, Prospective cohort study, Non motor symptoms, General Neuroscience, Parkinson's Disease Questionnaire, Aged, Female, Follow-Up Studies, Humans, Middle Aged, Parkinson Disease, Subthalamic Nucleus, Quality of Life, Neuroscience (all), Biophysics, Neurology (clinical), humanities, medicine.drug, medicine.medical_specialty, Levodopa, Scopa, Activities of Daily Living/psychology, lcsh:RC321-571, 03 medical and health sciences, Deep Brain Stimulation/methods, medicine, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, business.industry, Parkinson Disease/diagnosis, medicine.disease, Subthalamic Nucleus/physiology, 030104 developmental biology, Physical therapy, business, 030217 neurology & neurosurgery |
| الوصف: | BACKGROUND: Subthalamic nucleus (STN) deep brain stimulation (DBS) improves quality of life (QoL), motor, and non-motor symptoms (NMS) in advanced Parkinson's disease (PD). However, considerable inter-individual variability has been observed for QoL outcome.HYPOTHESIS: We hypothesized that demographic and preoperative NMS characteristics can predict postoperative QoL outcome.METHODS: In this ongoing, prospective, multicenter study (Cologne, Manchester, London) including 88 patients, we collected the following scales preoperatively and on follow-up 6 months postoperatively: PDQuestionnaire-8 (PDQ-8), NMSScale (NMSS), NMSQuestionnaire (NMSQ), Scales for Outcomes in PD (SCOPA)-motor examination, -complications, and -activities of daily living, levodopa equivalent daily dose. We dichotomized patients into "QoL responders"/"non-responders" and screened for factors associated with QoL improvement with (1) Spearman-correlations between baseline test scores and QoL improvement, (2) step-wise linear regressions with baseline test scores as independent and QoL improvement as dependent variables, (3) logistic regressions using aforementioned "responders/non-responders" as dependent variable.RESULTS: All outcomes improved significantly on follow-up. However, approximately 44% of patients were categorized as "QoL non-responders". Spearman-correlations, linear and logistic regression analyses were significant for NMSS and NMSQ but not for SCOPA-motor examination. Post-hoc, we identified specific NMS (flat moods, difficulties experiencing pleasure, pain, bladder voiding) as significant contributors to QoL outcome.CONCLUSIONS: Our results provide evidence that QoL improvement after STN-DBS depends on preoperative NMS characteristics. These findings are important in the advising and selection of individuals for DBS therapy. Future studies investigating motor and non-motor PD clusters may enable stratifying QoL outcomes and help predict patients' individual prospects of benefiting from DBS. |
| وصف الملف: | application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document |
| تدمد: | 1935-861X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5673875aedceff932ca091a37b1f247Test https://doi.org/10.1016/j.brs.2018.02.015Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f5673875aedceff932ca091a37b1f247 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1935861X |
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