التفاصيل البيبلوغرافية
| العنوان: |
Non-Invasive Quantitative Approximation of Intracranial Pressure in Pediatric Idiopathic Intracranial Hypertension Based on Point-of-Care Ultrasound of the Optic Nerve Sheath Diameter. |
| المؤلفون: |
Kerscher, Susanne Regina, Zipfel, Julian, Bevot, Andrea, Sollmann, Nico, Haas-Lude, Karin, Tellermann, Jonas, Schuhmann, Martin Ulrich |
| المصدر: |
Brain Sciences (2076-3425); Jan2024, Vol. 14 Issue 1, p32, 11p |
| مصطلحات موضوعية: |
INTRACRANIAL hypertension, OPTIC nerve, INTRACRANIAL pressure, ULTRASONIC imaging, POINT-of-care testing |
| مستخلص: |
Background: To investigate whether ultrasound-based optic nerve sheath diameter (US-ONSD) is a reliable measure to follow up children with idiopathic intracranial hypertension (IIH). In addition, to analyze the inter- and intra-individual relationships between US-ONSD and intracranial pressure (ICP), and to investigate whether an individualized mathematical regression equation obtained from two paired US-ONSD/ICP values can be used to approximate ICP from US-ONSD values. Methods: 159 US examinations and 53 invasive ICP measures via lumbar puncture (LP) were performed in 28 children with IIH. US-ONSD was measured using a 12 Mhz linear transducer and compared to ICP values. In 15 children, a minimum of 2 paired US-ONSD/ICP determinations were performed, and repeated-measures correlation (rmcorr) and intra-individual correlations were analyzed. Results: The cohort correlation between US-ONSD and ICP was moderate (r = 0.504, p < 0.01). Rmcorr (r = 0.91, p < 0.01) and intra-individual correlations (r = 0.956–1) of US-ONSD and ICP were excellent. A mathematical regression equation can be calculated from two paired US-ONSD/ICP values and applied to the individual patient to approximate ICP from US-ONSD. Conclusions: Related to excellent intra-individual correlations between US-ONSD and ICP, an individualized regression formula, created from two pairs of US-ONSD/ICP values, may be used to directly approximate ICP based on US-ONSD values. Hence, US-ONSD may become a non-invasive and reliable measure to control treatment efficacy in pediatric IIH. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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