التفاصيل البيبلوغرافية
| العنوان: |
Elevated Neurofilament Light Chain in Cerebrospinal Fluid and Plasma Reflect Inflammatory MRI Activity in Neurosarcoidosis. |
| المؤلفون: |
Byg, Keld-Erik, Nielsen, Helle H., Sejbaek, Tobias, Madsen, Jonna Skov, Olsen, Dorte Aalund, Nguyen, Nina, Kindt, Astrid, Grauslund, Jakob, Illes, Zsolt, Ellingsen, Torkell, Brahmajothi, Mulugu V. |
| المصدر: |
Brain Sciences (2076-3425); Feb2021, Vol. 11 Issue 2, p238, 1p |
| مصطلحات موضوعية: |
CEREBROSPINAL fluid, SARCOIDOSIS, CYTOPLASMIC filaments, CENTRAL nervous system, MAGNETIC resonance imaging |
| مستخلص: |
Background: Damage to axonal cells releases neurofilament light chain (NFL) into the cerebrospinal fluid and plasma. The objective of this study was to investigate NFL as a potential biomarker of disease activity in neurosarcoidosis. MRIs were graded according to enhancing lesions at different central nervous system (CNS) sites. Results: In cerebrospinal fluid, levels of NFL were higher in neurosarcoidosis patients (n = 20) median 2304 pg/mL (interquartile range (IQR) 630–19,612) compared to 426 pg/mL (IQR 261-571) in extra-neurologic sarcoidosis patients (n = 20) and 336 pg/mL (IQR 194–402) in healthy controls (n = 11) (p = 0.0002). In plasma, levels of NFL were higher in neurosarcoidosis patients median 28.2 pg/mL (IQR 11.5–49.3) compared to 6.2 pg/mL (IQR 4.3–8.2) in extra-neurologic sarcoidosis patients and 7.1 pg/mL (IQR 6.2–9.0) in healthy controls (p = 0.0001). Levels in both cerebrospinal fluid and plasma were higher in neurosarcoidosis patients with moderate/severe enhancement than patients with mild enhancement on MRI (p = 0.009 and p = 0.005, respectively). To distinguish neurosarcoidosis patients from extra-neurologic patients and healthy controls, a cut-off level of 630 pg/mL in cerebrospinal fluid had 94% specificity and 79% sensitivity, while a cut-off level of 11.4 pg/mL in plasma had 97% specificity and 75% sensitivity. Conclusions: NFL levels in cerebrospinal fluid and plasma are significantly higher in neurosarcoidosis patients compared to extra-neurologic patients and healthy controls, and the levels correlate to the extent of inflammation on MRI. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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