Sustained Axonal Degeneration in Prolonged Disorders of Consciousness
| العنوان: | Sustained Axonal Degeneration in Prolonged Disorders of Consciousness |
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| المؤلفون: | Antonio De Tanti, Maria Andriolo, Valeria Pingue, Maria Ursino, Sergio Bagnato, Antonio Nardone, Teresa Fiorilla, Teresa Barone, Cristina Boccagni, Lucia Francesca Lucca, Francesca Rubino, Serena Gennaro, Valentina Colombo, Maria Enza D'Ippolito, Pamela Salucci |
| المصدر: | Brain Sciences Volume 11 Issue 8 Brain Sciences, Vol 11, Iss 1068, p 1068 (2021) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | hypoxic-ischemic brain injury, Traumatic brain injury, Neurofilament light, Neurosciences. Biological psychiatry. Neuropsychiatry, Article, vegetative state, medicine, Persistent vegetative state, unresponsive wakefulness syndrome, business.industry, General Neuroscience, traumatic brain injury, Minimally conscious state, biomarkers of brain injury, medicine.disease, Pathophysiology, minimally conscious state, neurofilament light chain, Neurology, secondary brain injury, Anesthesia, Etiology, Wakefulness, Neurology (clinical), business, Axonal degeneration, RC321-571 |
| الوصف: | (1) Background: Sustained axonal degeneration may play a critical role in prolonged disorder of consciousness (DOCs) pathophysiology. We evaluated levels of neurofilament light chain (NFL), an axonal injury marker, in patients with unresponsive wakefulness syndrome (UWS) and in the minimally conscious state (MCS) after traumatic brain injury (TBI) and hypoxic-ischemic brain injury (HIBI). (2) Methods: This prospective multicenter blinded study involved 70 patients with prolonged DOC and 70 sex-/age-matched healthy controls. Serum NFL levels were evaluated at 1–3 and 6 months post-injury and compared with those of controls. NFL levels were compared by DOC severity (UWS vs. MCS) and etiology (TBI vs. HIBI). (3) Results: Patients’ serum NFL levels were significantly higher than those of controls at 1–3 and 6 months post-injury (medians, 1729 and 426 vs. 90 pg/mL both p < 0.0001). NFL levels were higher in patients with UWS than in those in MCS at 1–3 months post-injury (p = 0.008) and in patients with HIBI than in those with TBI at 6 months post-injury (p = 0.037). (4) Conclusions: Patients with prolonged DOC present sustained axonal degeneration that is affected differently over time by brain injury severity and etiology. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2076-3425 |
| DOI: | 10.3390/brainsci11081068 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10ee04abe093eb35169451f6fddedc53Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....10ee04abe093eb35169451f6fddedc53 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763425 |
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| DOI: | 10.3390/brainsci11081068 |