التفاصيل البيبلوغرافية
| العنوان: |
Cholecystokinin-33 is more effective than cholecystokinin-8 in inhibiting food intake and in stimulating the myenteric plexus and dorsal vagal complex |
| المؤلفون: |
Cooper, Marvis S.1, Reeve, Joseph R.2, Abdalla, Mohamed O.1, Moyer, Laura1, Raboin, Shannon J.1, Green, Gary M.3, Sayegh, Ayman I.1 sayeghai@tuskegee.edu |
| المصدر: |
Brain Research. Apr2008, Vol. 1205, p27-35. 9p. |
| مصطلحات موضوعية: |
*CHOLECYSTOKININ, *MYENTERIC plexus, *INGESTION, *NERVOUS system |
| مستخلص: |
Abstract: We compared the abilities of cholecystokinin-33 (CCK-33) and CCK-8 to reduce food intake and to activate feeding-related areas of the nervous system. (1) Overnight food-deprived rats were presented with a 10% sucrose solution, and intake was measured at 5-min intervals throughout a 90-min test beginning immediately after intraperitoneal injections of 1, 3, or 5 nMol/kg of CCK-33, CCK-8, or the vehicle control. In the initial 20 min (first meal), both peptides were equally effective, producing large reductions of food intake. Thereafter, however, CCK-33 was more effective than CCK-8, producing much more sustained reductions. Overall, both peptides reduced total food intake, but CCK-33 was more effective than CCK-8. (2) Possible roles for the myenteric plexus of the duodenum and the dorsal vagal complex (DVC) of the brainstem in the differential satiety effects of CCK-33 and CCK-8 were examined by quantifying CCK-33- and CCK-8-stimulated Fos-like immunoreactivity (Fos-LI) in each site. Consistent with the greater ability of CCK-33 to produce sustained inhibitions of food intake, CCK-33 produced more Fos-LI than CCK-8 in nearly every section of the sampled sites. The results demonstrate: (1) Different forms of CCK have different efficacies in reducing food intake; (2) CCK-33 produces a much more prolonged satiety action than CCK-8; and (3) the myenteric plexus and DVC may play roles in these differential satiety actions. [Copyright &y& Elsevier] |
| قاعدة البيانات: |
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