التفاصيل البيبلوغرافية
| العنوان: |
Alleviative effects of foraging exercise on depressive-like behaviors in chronic mild stress-induced ischemic rat model. |
| المؤلفون: |
Tao, Xi1 taoxi567@hunnu.edu.cn, Wu, Siyuan1, Tang, Wenjing1, Li, Lu1, Huang, Lijun1, Mo, Danheng2, Liu, Chujuan1, Song, Tao1, Wang, Shuling3, Wang, Jia4, He, Juan5 |
| المصدر: |
Brain Injury. 2022, Vol. 36 Issue 1, p127-136. 10p. |
| مصطلحات موضوعية: |
*PREVENTION of mental depression, *BIOLOGICAL models, *STATISTICS, *BODY weight, *ANALYSIS of variance, *ISCHEMIC stroke, *ANIMAL experimentation, *EXERCISE physiology, *RATS, *T-test (Statistics), *EXERCISE, *DESCRIPTIVE statistics, *ENZYME-linked immunosorbent assay, *DATA analysis software, *DATA analysis, *DISEASE complications |
| مستخلص: |
Poststroke depression (PSD) is a common complication that seriously affects the functional recovery and prognosis of an individual. As some patients with PSD fail to respond to drug therapy, it is urgent to find a viable alternative treatment. An active exercise program known as foraging exercise (FE), using food as bait, was designed. First, focal ischemia and chronic unpredictable mild stress (CUMS) were used to establish a PSD model in rats. FE was then performed for 4 weeks. Body weight and behavioral assessments were conducted at the end of the 4th and 8th weeks. After 8 weeks, the results revealed that, compared with the PSD group, the behavioral scores of the rats in the PSD/FE group were significantly improved, the expression of Iba-1 in the affected frontal lobe and striatum was decreased, and serum levels of IL-6 and the IL-6/IL-10 ratio were downregulated. However, the ratio of residual brain volume in rats that had experienced CUMS was significantly less than that in the stroke group. FE can alleviate the behavioral scores of PSD rats, and its mechanism may be related to a modulation of the immune-inflammation response of microglia. Furthermore, chronic, persistent stress may increase the volume of cerebral infarction after stroke. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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