التفاصيل البيبلوغرافية
العنوان:
Peak width of skeletonized mean diffusivity (PSMD) and cognitive functions in relapsing-remitting multiple sclerosis
المؤلفون:
Claudia Vinciguerra , Maria Pia Amato , V Nardone , Claudia Niccolai , Jian Zhang , R. Tappa Brocci , M. L. Stromillo , Antonio Giorgio , Luisa Pastò , M. Mortilla , N. De Stefano
المساهمون:
Vinciguerra, C., Giorgio, A., Zhang, J., Nardone, V., Tappa Brocci, R., Pasto, L., Niccolai, C., Stromillo, M. L., Mortilla, M., Amato, M. P., De Stefano, N.
المصدر:
Brain imaging and behavior . 15(4)
سنة النشر:
2020
مصطلحات موضوعية:
Multiple Sclerosis , Cognitive Neuroscience , Grey matter , 050105 experimental psychology , White matter , 03 medical and health sciences , Behavioral Neuroscience , Cellular and Molecular Neuroscience , 0302 clinical medicine , Atrophy , Cognition , DTI , MRI , Multiple sclerosis , PSMD , Multiple Sclerosis, Relapsing-Remitting , Visual memory , medicine , Verbal fluency test , Humans , 0501 psychology and cognitive sciences , Radiology, Nuclear Medicine and imaging , Multiple sclerosi , Neuroradiology , business.industry , 05 social sciences , Neuropsychology , medicine.disease , Magnetic Resonance Imaging , Psychiatry and Mental health , medicine.anatomical_structure , Diffusion Tensor Imaging , Neurology , Neurology (clinical) , business , Nuclear medicine , 030217 neurology & neurosurgery , Diffusion MRI
الوصف:
Peak width of skeletonized mean diffusivity (PSMD) is a new MRI marker, which has shown clinical relevance in some neurological conditions and, in preliminary data, in multiple sclerosis (MS). We aimed here to investigate, in a group of relapsing-remitting MS (RRMS) patients, the relationship between PSMD and cognitive performances, in comparison with other MRI measures. RRMS patients (n= 60) and normal controls (n= 15) underwent a 3T MRI examination. MRI-based white matter (WM) lesion volume, microstructural integrity (assessed with Tract-Based Spatial Statistics of diffusion tensor imaging [DTI] images) and brain volumes (i.e., total brain, grey matter [GM] and WM) were computed. In addition, PSMD was calculated through “skeletonization” of WM tracts and diffusion histograms. Cognition was evaluated with Rao’s Brief Repeatable Battery (BRB), which incorporated tests of verbal and visual memory, attention, concentration, information processing speed and verbal fluency. PSMD closely correlated with symbol digit modalities test (SDMT) (r = −0.70, p< 0.001)and, to a lesser extent, with verbal and visual memory tests. Multiple regression analysis showed that PSMD explained SDMT variance (R2= 0.54, p< 0.001) more than other MRI measures. Results point out the relevance of microstructural damage, as assessed by PSMD, as a reliable marker of cognition in MS, especially in explaining dysfunction in information processing speed. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.
تدمد:
1931-7565
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e48b88845affe56964cea28121d0a01Test https://pubmed.ncbi.nlm.nih.gov/33033983Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....8e48b88845affe56964cea28121d0a01
قاعدة البيانات:
OpenAIRE
