Children with Autism Spectrum Disorder Demonstrate Regionally Specific Altered Resting-State Phase–Amplitude Coupling
| العنوان: | Children with Autism Spectrum Disorder Demonstrate Regionally Specific Altered Resting-State Phase–Amplitude Coupling |
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| المؤلفون: | Jeffrey I. Berman, J. Christopher Edgar, Timothy P.L. Roberts, Marissa Dipiero, Song Liu, Russell G. Port, Lisa Blaskey, Matthew Ku, Emily S. Kuschner |
| المصدر: | Brain Connect |
| بيانات النشر: | Mary Ann Liebert Inc, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, endocrine system diseases, Autism Spectrum Disorder, Rest, education, Alpha (ethology), 050105 experimental psychology, 03 medical and health sciences, Social Responsiveness Scale, 0302 clinical medicine, health services administration, Neural Pathways, Gamma Rhythm, Humans, Medicine, 0501 psychology and cognitive sciences, Child, Brain Mapping, Resting state fMRI, business.industry, General Neuroscience, 05 social sciences, Brain, Magnetoencephalography, food and beverages, Original Articles, medicine.disease, Magnetic Resonance Imaging, humanities, Electrophysiological Phenomena, Large sample, Alpha Rhythm, Electrophysiology, Autism spectrum disorder, Female, business, Neuroscience, Alpha power, 030217 neurology & neurosurgery, Phase amplitude coupling |
| الوصف: | Studies suggest that individuals with autism spectrum disorder (ASD) exhibit altered electrophysiological alpha to gamma phase-amplitude coupling (PAC). Preliminary reports with small samples report conflicting findings regarding the directionality of the alpha to gamma PAC alterations in ASD. The present study examined resting-state activity throughout the brain in a relatively large sample of 119 children with ASD and 47 typically developing children. Children with ASD demonstrated regionally specific abnormalities in alpha to low-gamma PAC, with increased alpha to low-gamma PAC for a central midline source and decreased PAC at lateral sources. Group differences in local gamma-band power did not account for the regional group differences in alpha to low-gamma PAC. Moreover, local alpha power did not significantly modulate alpha to low-gamma PAC estimates. Finally, PAC estimates were correlated with Social Responsiveness Scale (SRS) indicating clinical relevance of the PAC metric. In conclusion, alpha to low-gamma PAC alterations in ASD demonstrate a heterogeneous spatial profile consistent with previous studies and were related to symptom severity. |
| تدمد: | 2158-0022 2158-0014 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f46271175259d73b1d333be9484ee3fcTest https://doi.org/10.1089/brain.2018.0653Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f46271175259d73b1d333be9484ee3fc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21580022 21580014 |
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