Sex-biased gene expression in the frontal cortex of common marmosets (Callithrix jacchus ) and potential behavioral correlates
| العنوان: | Sex-biased gene expression in the frontal cortex of common marmosets (Callithrix jacchus ) and potential behavioral correlates |
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| المؤلفون: | Maria Bernardete Cordeiro de Sousa, Danilo Oliveira Imparato, Viviane Brito Nogueira, Sandro J. de Souza |
| المصدر: | Repositório Institucional da UFRN Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN Brain and Behavior |
| بيانات النشر: | Wiley, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Adaptive strategies, neuropsychiatric primate model, Gene Expression, adaptive strategies, transcriptomics, 03 medical and health sciences, Behavioral Neuroscience, Cognition, 0302 clinical medicine, biology.animal, Neuroplasticity, Gene expression, Animals, Humans, database, Original Research, New World monkey, Sex Characteristics, Neuronal Plasticity, synaptic plasticity, Behavior, Animal, biology, Alternative splicing, High-Throughput Nucleotide Sequencing, Marmoset, Callithrix, biology.organism_classification, Frontal Lobe, Sexual dimorphism, 030104 developmental biology, sexual dimorphism, Synaptic plasticity, Visual Perception, Female, Transcriptome, Neuroscience, Stress, Psychological, 030217 neurology & neurosurgery |
| الوصف: | INTRODUCTION: The common marmoset (Callithrix jacchus), a small New World monkey, has been widely used as a biological model in neuroscience to elucidate neural circuits involved in cognition and to understand brain dysfunction in neuropsychiatric disorders. In this regard, the availability of gene expression data derived from next-generation sequencing (NGS) technologies represents an opportunity for a molecular contextualization. Sexual dimorphism account for differences in diseases prevalence and prognosis. Here, we explore sex differences on frontal cortex of gene expression in common marmoset's adults. METHODS: Gene expression profiles in six different tissues (cerebellum, frontal cortex, liver, heart, and kidney) were analyzed in male and female marmosets. To emphasize the translational value of this species for behavioral studies, we focused on sex-biased gene expression from the frontal cortex of male and female in common marmosets and compared to humans (Homo sapiens). RESULTS: In this study, we found that frontal cortex genes whose expression is male-biased are conserved between marmosets and humans and enriched with "house-keeping" functions. On the other hand, female-biased genes are more related to neural plasticity functions involved in remodeling of synaptic circuits, stress cascades, and visual behavior. Additionally, we developed and made available an application-the CajaDB-to provide a friendly interface for genomic, expression, and alternative splicing data of marmosets together with a series of functionalities that allow the exploration of these data. CajaDB is available at cajadb.neuro.ufrn.br. CONCLUSION: The data point to differences in gene expression of male and female common marmosets in all tissues analyzed. In frontal cortex, female-biased expression in synaptic plasticity, stress, and visual processing might be linked to biological and behavioral mechanisms of this sex. Due to the limited sample size, the data here analyzed are for exploratory purposes. |
| تدمد: | 2162-3279 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad011b446b9d77e1a7b2b7adc127d57Test https://doi.org/10.1002/brb3.1148Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dad011b446b9d77e1a7b2b7adc127d57 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21623279 |
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