Behavioural cues are associated with modulations of synchronous oscillations in the human subthalamic nucleus
| العنوان: | Behavioural cues are associated with modulations of synchronous oscillations in the human subthalamic nucleus |
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| المؤلفون: | Gary Hotton, David E. Williams, Andrea A. Kühn, Hans Speelman, Kielan Yarrow, Peter Brown, Marina A. J. Tijssen, Andreas Kupsch, Gerard van Bruggen |
| المساهمون: | Amsterdam Neuroscience, Neurology |
| المصدر: | Brain, 126(Part 9), 1975-1985. Oxford University Press |
| بيانات النشر: | Oxford University Press (OUP), 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | Male, Parkinson's disease, Local field potential, Stimulus (physiology), Basal Ganglia, Beta band, Synchronous oscillations, Biological Clocks, Subthalamic Nucleus, Basal ganglia, Reaction Time, medicine, Humans, Premovement neuronal activity, Aged, Electroencephalography, Parkinson Disease, Signal Processing, Computer-Assisted, Middle Aged, medicine.disease, Subthalamic nucleus, Female, Neurology (clinical), Cues, Psychology, Neuroscience, Photic Stimulation |
| الوصف: | The speed with which one reacts to an imperative signal depends on the extent to which preceding cues predict that command. When reliable warning cues are available, the processing of the imperative stimulus can be favoured and responses partially pre-prepared, leading to shorter reaction times. Here we seek evidence for involvement of the human basal ganglia in the exploitation of behaviourally relevant predictive cues. To this end, local field potentials (LFPs) were recorded in the region of the subthalamic nuclei of parkinsonian patients during the performance of a pre-cued reaction task in which the cue either predicted or failed to predict the demands of the imperative signal. We demonstrate that LFP activity in the beta frequency band ( approximately 20 Hz) is modulated by the behavioural relevance of the external cue. The findings suggest that, first, the subthalamic nucleus is involved in mediating or facilitating the response advantage derived from predictive cues in humans and, secondly, variations in synchronous neuronal activity in the beta band may contribute to this function in the subthalamic nucleus. |
| تدمد: | 1460-2156 0006-8950 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb517c00668ccef48f124b01093c5bffTest https://doi.org/10.1093/brain/awg194Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bb517c00668ccef48f124b01093c5bff |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602156 00068950 |
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