Dysregulated oscillatory connectivity in the visual system in autism spectrum disorder
| العنوان: | Dysregulated oscillatory connectivity in the visual system in autism spectrum disorder |
|---|---|
| المؤلفون: | Gerard Gooding-Williams, Jan-Mathijs Schoffelen, Georgina Rippon, Klaus Kessler, Robert A. Seymour |
| المصدر: | Brain Brain, 142, 10, pp. 3294-3305 Brain, 142, 3294-3305 |
| بيانات النشر: | Oxford University Press (OUP), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, phase-amplitude coupling, 110 000 Neurocognition of Language, Adolescent, Sensory processing, Autism Spectrum Disorder, media_common.quotation_subject, medicine.medical_treatment, ASD, Visual processing, 03 medical and health sciences, 0302 clinical medicine, Perception, Neural Pathways, Connectome, medicine, Gamma Rhythm, Humans, Gray Matter, Visual hierarchy, media_common, 030304 developmental biology, Granger causality connectivity, 0303 health sciences, medicine.diagnostic_test, Brain, Magnetoencephalography, Electroencephalography, Original Articles, medicine.disease, Alpha Rhythm, Autism spectrum disorder, oscillations, Visual Perception, visual system, Autism, Female, Occipital Lobe, Neurology (clinical), Psychology, Occipital lobe, Neuroscience, 030217 neurology & neurosurgery, Neurotypical |
| الوصف: | Autism Spectrum Disorder is often accompanied by sensory symptoms. Using magnetoencephalography to measure gamma and alpha band cortical activity in affected individuals, Seymour et al. corroborate the hypothesis that aberrant sensory processing is linked to atypical functional connectivity within and between areas of the visual system. Autism spectrum disorder is increasingly associated with atypical perceptual and sensory symptoms. Here we explore the hypothesis that aberrant sensory processing in autism spectrum disorder could be linked to atypical intra- (local) and interregional (global) brain connectivity. To elucidate oscillatory dynamics and connectivity in the visual domain we used magnetoencephalography and a simple visual grating paradigm with a group of 18 adolescent autistic participants and 18 typically developing control subjects. Both groups showed similar increases in gamma (40–80 Hz) and decreases in alpha (8–13 Hz) frequency power in occipital cortex. However, systematic group differences emerged when analysing intra- and interregional connectivity in detail. First, directed connectivity was estimated using non-parametric Granger causality between visual areas V1 and V4. Feedforward V1-to-V4 connectivity, mediated by gamma oscillations, was equivalent between autism spectrum disorder and control groups, but importantly, feedback V4-to-V1 connectivity, mediated by alpha (8–13 Hz) oscillations, was significantly reduced in the autism spectrum disorder group. This reduction was positively correlated with autistic quotient scores, consistent with an atypical visual hierarchy in autism, characterized by reduced top-down modulation of visual input via alpha-band oscillations. Second, at the local level in V1, coupling of alpha-phase to gamma amplitude (alpha-gamma phase amplitude coupling) was reduced in the autism spectrum disorder group. This implies dysregulated local visual processing, with gamma oscillations decoupled from patterns of wider alpha-band phase synchrony (i.e. reduced phase amplitude coupling), possibly due to an excitation-inhibition imbalance. More generally, these results are in agreement with predictive coding accounts of neurotypical perception and indicate that visual processes in autism are less modulated by contextual feedback information. |
| وصف الملف: | application/pdf |
| تدمد: | 1460-2156 0006-8950 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e223e7cb10c012d9d30ad282a474a0b9Test https://doi.org/10.1093/brain/awz214Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e223e7cb10c012d9d30ad282a474a0b9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602156 00068950 |
|---|