التفاصيل البيبلوغرافية
| العنوان: |
Peripheral blood stem cell mobilization by granulocyte colony-stimulating factor alone and engraftment kinetics following autologous transplantation in children and adolescents with solid tumor. |
| المؤلفون: |
Watanabe, H., Watanabe, T., Suzuya, H., Wakata, Y., Kaneko, M., Onishi, T., Okamoto, Y., Abe, T., Kawano, Y., Kagami, S., Takaue, Y. |
| المصدر: |
Bone Marrow Transplantation; Apr2006, Vol. 37 Issue 7, p661-668, 8p, 3 Charts, 2 Graphs |
| مصطلحات موضوعية: |
STEM cells, GRANULOCYTES, AUTOTRANSPLANTATION, TUMORS, BLOOD platelets |
| مستخلص: |
In 56 pediatric and adolescent patients (median age 7 years, range 1–21) with various solid tumors, peripheral blood stem cells (PBSC) were mobilized with granulocyte colony-stimulating factor (G-CSF) alone, and the yields of PBSC and engraftment kinetics following autologous peripheral blood stem cell transplantation (PBSCT) were evaluated retrospectively. Granulocyte colony-stimulating factor (10 μg/kg) was injected subcutaneously for mobilization when patients showed no influence of previous chemotherapy, and administration was continued for 5 days. The peaks of CD34+ cells and colony-forming units-granulocyte/macrophage in the blood were observed on days 4 through 6 of G-CSF administration in all patients. Peripheral blood stem cell harvest was commenced on day 5 of G-CSF treatment. Compared to the results in patients mobilized by chemotherapy plus G-CSF (N=18), the progenitor cell yields were lower in patients mobilized with G-CSF alone. However, there were no significant differences in WBC and ANC engraftment compared to the chemotherapy plus G-CSF mobilization group. Platelet recovery following autologous PBSCT was delayed in patients mobilized with G-CSF alone. The median time taken for ANC and platelet counts to reach 0.5 × 109 and 20 × 109/l was 12 days (range: 9–28) and 15 days (8–55), respectively, in all patients who received PBSC mobilized by G-CSF alone. In summary, mobilization with G-CSF alone can mobilize sufficient CD34+ cells for successful autografting and sustained hematological reconstitution in pediatric and adolescent patients with solid tumors, and even in heavily pre-treated patients.Bone Marrow Transplantation (2006) 37, 661–668. doi:10.1038/sj.bmt.1705304; published online 20 February 2006 [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
