دورية أكاديمية
Epstein-Barr virus infection of infants: implications of early age of infection on viral control and risk for Burkitt lymphoma
العنوان: | Epstein-Barr virus infection of infants: implications of early age of infection on viral control and risk for Burkitt lymphoma |
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المؤلفون: | Rosemary Rochford |
المصدر: | Boletín Médico del Hospital Infantil de México, Vol 73, Iss 1, Pp 41-46 (2016) |
بيانات النشر: | Permanyer, 2016. |
سنة النشر: | 2016 |
المجموعة: | LCC:Pediatrics LCC:Public aspects of medicine |
مصطلحات موضوعية: | Epstein-Barr virus, Burkitt lymphoma, Plasmodium falciparum, Malaria, Activation induced cytidine deaminase, Pediatrics, RJ1-570, Public aspects of medicine, RA1-1270 |
الوصف: | Since its first description by Denis Burkitt, endemic Burkitt's lymphoma (BL), the most common childhood cancer in sub-Saharan Africa, has led scientists to search for clues to the origins of this malignancy. The discovery of Epstein-Barr virus (EBV) in BL cells over 50 years ago led to extensive sero-epidemiology studies and revealed that rather than being a virus restricted to areas where BL is endemic, EBV is ubiquitous in the world's population with an estimated greater than 90% of adults worldwide infected. A second pathogen, Plasmodium falciparum (P. falciparum) malaria is also linked to BL. In this review, we will discuss recent studies that indicate a role for P. falciparum malaria in dysregulating EBV infection, and increasing the risk for BL in children living where P. falciparum malaria transmission is high. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English Spanish; Castilian |
تدمد: | 1665-1146 |
العلاقة: | http://www.sciencedirect.com/science/article/pii/S1665114615002385Test; https://doaj.org/toc/1665-1146Test |
DOI: | 10.1016/j.bmhimx.2015.12.001 |
الوصول الحر: | https://doaj.org/article/00cff61a4f554923853381249b7392e4Test |
رقم الانضمام: | edsdoj.00cff61a4f554923853381249b7392e4 |
قاعدة البيانات: | Directory of Open Access Journals |
تدمد: | 16651146 |
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DOI: | 10.1016/j.bmhimx.2015.12.001 |