Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes
| العنوان: | Coxsackie-adenovirus receptor expression is enhanced in pancreas from patients with type 1 diabetes |
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| المؤلفون: | Hodik, M., Anagandula, M., Fuxe, J., Krogvold, L., Dahl Jørgensen, K., Hyã¶ty, H., Sarmiento, L., Frisk, G, Atkinson, Mark, Pugliese, Alberto, Campbell Thompson, Martha, Kaddis, John, Kusmartseva, Irina, Yang, Mingder, Clare Salzler, Michael, Chapman, Nora, Tracy, Steven, Smithee, Shane, Alhazmi, Abdulaziz, Frisk, Gun, Anagandula, Mahesh, Sarimiento, Luis, Giepmans, Ben, Kalicharan, Ruby, Kuipers, Jeroen, Wolters, Anouk, Jelmer, Willems, Morgan, Noel, Richardson, Sarah, Dyahal, Shalinee, Russell, Mark, Leete, Pia, Nadler, Jerry, Morris, Margaret, Nyalwidhe, Julius, Burch, Tayna, von Herrath, Matthias, Rodriguez Calvo, Teresa, Sabouri, Somayeh, Anquetil Besnard, Florence, Plagnol, Vincent, Breuer, Judith, Depledge, Daniel, Dotta, Francesco, Sebastiani, Guido, Patti, Aurora, Nigi, Laura, Ventriglia, Giuliana, Mancarella, Francesca, Gerling, Ivan, Kakoola, Dorothy, Lenchik, Nataliya, Hyã¶ty, Heikki, Laiho, Jutta, Oikarnen, Maarit, Eizirik, Decio, Opdebeeck, Anne, Lloyd, Richard, Petrosino, Joseph, Homann, Dirk, Kent, Sally, Sarkar, Suparna, Toniolo, Antonio, Gianani, Roberto, Horwitz, Marc, Marjomaki, Varpu, Flodström Tullberg, Malin, Domsgen, Erna, Larsson, Pã¤r, PIEMONTI, LORENZO |
| المساهمون: | Hodik, M., Anagandula, M., Fuxe, J., Krogvold, L., Dahl Jørgensen, K., Hyã¶ty, H., Sarmiento, L., Frisk, G, Atkinson, Mark, Pugliese, Alberto, Campbell Thompson, Martha, Kaddis, John, Kusmartseva, Irina, Yang, Mingder, Clare Salzler, Michael, Chapman, Nora, Tracy, Steven, Smithee, Shane, Alhazmi, Abdulaziz, Frisk, Gun, Anagandula, Mahesh, Sarimiento, Lui, Giepmans, Ben, Kalicharan, Ruby, Kuipers, Jeroen, Wolters, Anouk, Jelmer, Willem, Morgan, Noel, Richardson, Sarah, Dyahal, Shalinee, Russell, Mark, Leete, Pia, Nadler, Jerry, Morris, Margaret, Nyalwidhe, Juliu, Burch, Tayna, von Herrath, Matthia, Rodriguez Calvo, Teresa, Sabouri, Somayeh, Anquetil Besnard, Florence, Plagnol, Vincent, Breuer, Judith, Depledge, Daniel, Dotta, Francesco, Sebastiani, Guido, Patti, Aurora, Nigi, Laura, Ventriglia, Giuliana, Mancarella, Francesca, Gerling, Ivan, Kakoola, Dorothy, Lenchik, Nataliya, Hyã¶ty, Heikki, Laiho, Jutta, Oikarnen, Maarit, Eizirik, Decio, Opdebeeck, Anne, Lloyd, Richard, Petrosino, Joseph, Homann, Dirk, Kent, Sally, Sarkar, Suparna, Toniolo, Antonio, Gianani, Roberto, Piemonti, Lorenzo, Horwitz, Marc, Marjomaki, Varpu, Flodström Tullberg, Malin, Domsgen, Erna, Larsson, Pã¤r |
| المصدر: | BMJ Open Diabetes Research & Care |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Chemokine, endocrine system, Receptor(s), endocrine system diseases, Endocrinology, Diabetes and Metabolism, Endocrinology and Diabetes, Proinflammatory cytokine, 03 medical and health sciences, Internal medicine, medicine, Receptor, Islet of Langerhans, geography, geography.geographical_feature_category, Islet of Langerhan, Type 1, Virus, biology, business.industry, Viru, Pancreatic islets, Islet, Reverse transcription polymerase chain reaction, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Islet Studies, Endokrinologi och diabetes, biology.protein, Immunohistochemistry, Pancreas, business |
| الوصف: | Objectives: One of the theories connecting enterovirus (EV) infection of human islets with type 1 diabetes (T1D) is the development of a fertile field in the islets. This implies induction of appropriate proteins for the viral replication such as the coxsackie-adenovirus receptor (CAR). The aim of this study was to investigate to what extent CAR is expressed in human islets of Langerhans, and what conditions that would change the expression. Design: Immunohistochemistry for CAR was performed on paraffin-embedded pancreatic tissue from patients with T1D (n=9 recent onset T1D, n=4 long-standing T1D), islet autoantibody-positive individuals (n=14) and non-diabetic controls (n=24) individuals. The expression of CAR was also examined by reverse transcription PCR on microdissected islets (n=5), exocrine tissue (n=5) and on explanted islets infected with EV or exposed to chemokines produced by EV-infected islet cells. Results: An increased frequency of patients with T1D and autoantibody-positive individuals expressed CAR in the pancreas (p |
| وصف الملف: | application/pdf |
| تدمد: | 2052-4897 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dbe42b202fe6a872f94015c99ac468aTest https://pubmed.ncbi.nlm.nih.gov/27933184Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7dbe42b202fe6a872f94015c99ac468a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20524897 |
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