التفاصيل البيبلوغرافية
| العنوان: |
Trajectories in HbA1c and other risk factors among adults with type 1 diabetes by age at onset |
| المؤلفون: |
Edqvist, Jon, 1988, Rawshani, Araz, 1986, Rawshani, Aidin, 1991, Adiels, Martin, 1976, Franzén, S., Björck, Lena, 1959, Svensson, A. M., Lind, Marcus, 1976, Sattar, N., Rosengren, Annika, 1951 |
| المصدر: |
BMJ Open Diabetes Research and Care. 9(1) |
| مصطلحات موضوعية: |
Endocrinology and Diabetes, Endokrinologi och diabetes, albuminuria, cardiovascular system, diabetes mellitus, glycated hemoglobin A, type 1, hemoglobin A1c, low density lipoprotein cholesterol, glycosylated hemoglobin, adolescent, adult, aged, albumin to creatinine ratio, Article, body mass, diastolic blood pressure, estimated glomerular filtration rate, female, glycemic control, glycemic load, human, insulin dependent diabetes mellitus, macroalbuminuria, male, microalbuminuria, onset age, systolic blood pressure, risk factor, Age of Onset, Diabetes Mellitus, Type 1, Humans, Risk Factors |
| الوصف: |
In type 1 diabetes, potential loss of life-years is greatest in those who are youngest at the time of onset. Using data from a nationwide cohort of patients with type 1 diabetes, we aimed to study risk factor trajectories by age at diagnosis. We stratified 30005 patients with type 1 diabetes aged 18–75 years into categories based on age at onset: 0–10, 11–15, 16–20, 21–25, and 26–30 years. HbA1c, albuminuria, estimated glomerular filtration rate (eGFR), body mass index (BMI), low-denisty lipoprotein (LDL)-cholesterol, systolic blood pressure (SBP), and diastolic blood pressure trends were analyzed using mixed models. Variable importance for baseline HbA1c was analyzed using conditional random forest and gradient boosting machine approaches. Individuals aged ≥16 years at onset displayed a relatively low mean HbA1c level (~55–57mmol/mol) that gradually increased. In contrast, individuals diagnosed at ≤15 years old entered adulthood with a mean HbA1c of approximately 70mmol/mol. For all groups, HbA1c levels stabilized at a mean of approximately 65mmol/mol by about 40 years old. In patients who were young at the time of onset, albuminuria appeared at an earlier age, suggesting a more rapid decrease in eGFR, while there were no distinct differences in BMI, SBP, and LDL-cholesterol trajectories between groups. Low education, higher age, and poor risk factor control were associated with higher HbA1c levels. Young age at the diabetes onset plays a substantial role in subsequent glycemic control and the presence of albuminuria, where patients with early onset may accrue a substantial glycemic load during this period. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ. |
| الوصول الحر: |
https://gup.ub.gu.se/publication/306480Test |
| قاعدة البيانات: |
SwePub |
