التفاصيل البيبلوغرافية
العنوان:
Incidence and risk factors for mortality and end-stage renal disease in people with type 2 diabetes and diabetic kidney disease: A population-based cohort study in the UK
المؤلفون:
González-Pérez, A. , Saez, M. , Vizcaya, D. , Lind, Marcus , 1976, Garcia Rodriguez, L.
المصدر:
BMJ Open Diabetes Research and Care . 9(1)
مصطلحات موضوعية:
Endocrinology and Diabetes , Endokrinologi och diabetes , Public Health , Global Health , Social Medicine and Epidemiology , Folkhälsovetenskap , global hälsa , socialmedicin och epidemiologi , chronic , epidemiology , kidney failure , mortality , risk factors , glucagon like peptide 1 receptor agonist , metformin , mineralocorticoid antagonist , adult , aged , albumin to creatinine ratio , albuminuria , all cause mortality , Article , body mass , cohort analysis , diabetic nephropathy , end stage renal disease , estimated glomerular filtration rate , female , follow up , glycemic control , human , incidence , kidney function , major clinical study , male , middle aged , non insulin dependent diabetes mellitus , obesity , outcome assessment , proteinuria , risk assessment , risk factor , underweight , United Kingdom , very elderly
الوصف:
Introduction We aimed to determine the incidence of, and risk factors for all-cause/cardiovascular disease (CVD) mortality, and end-stage renal disease (ESRD) among people with type 2 diabetes with/without diabetic kidney disease (DKD) in the UK general population. Research design and methods We undertook a population-based cohort study using primary care UK electronic health records. We followed 8413 people with type 2 diabetes and DKD and a matched comparison cohort of people with type 2 diabetes without DKD. Risk factors for all-cause/CVD mortality (using both cohorts) and ESRD (DKD cohort only) were evaluated by estimating HRs with 95% CIs using Cox regression. Results In the DKD cohort (mean age 66.7 years, 62.4% male), incidence rates per 1000 person-years were 50.3 (all-cause mortality), 8.0 (CVD mortality) and 6.9 (ESRD). HRs (95% CIs; DKD vs comparison cohort) were 1.49 (1.35 to 1.64) for all-cause mortality and 1.60 (1.24 to 2.05) for CVD mortality. In general, higher all-cause mortality risks were seen with older age, underweight (body mass index <20 kg/m 2), reduced renal function, and cardiovascular/liver disease, and lower risks were seen with being female or overweight. In the DKD cohort, higher risks of ESRD were seen with reduced renal function at baseline, high material deprivation, cancer and non-insulin glucose-lowering drugs, and a lower risk was seen with overweight (≥25 kg/m 2). Conclusions Annually, one death will occur among every 20 people with type 2 diabetes and DKD. The identified risk factors in this study will help identify people with type 2 diabetes at most risk of death and progression of kidney disease, and help to direct effective management strategies. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
الوصول الحر:
https://gup.ub.gu.se/publication/314378Test
قاعدة البيانات:
SwePub
