Serum microRNA as indicators of Wolfram syndrome’s progression in neuroimaging studies
| العنوان: | Serum microRNA as indicators of Wolfram syndrome’s progression in neuroimaging studies |
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| المؤلفون: | Maciej Borowiec, Agnieszka Zmysłowska, Arleta Waszczykowska, Dobromila Baranska, Wojciech Fendler, Zuzanna Nowicka, Marcin Stanczak, Wojciech Młynarski |
| المصدر: | BMJ Open Diabetes Research & Care BMJ Open Diabetes Research & Care, Vol 8, Iss 2 (2020) |
| بيانات النشر: | BMJ Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Wolfram syndrome, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Neuroimaging, lcsh:Diseases of the endocrine glands. Clinical endocrinology, Tungsten, 03 medical and health sciences, 0302 clinical medicine, genetic diseases, Diabetes mellitus, Internal medicine, Germany, microRNA, medicine, Humans, Serum microrna, Type 1 diabetes, lcsh:RC648-665, business.industry, Neurodegeneration, biomarkers, Genetics/Genomes/Proteomics/Metabolomics, Wolfram Syndrome, medicine.disease, Clinical trial, MicroRNAs, type 1, diabetes mellitus, inborn, business, 030217 neurology & neurosurgery |
| الوصف: | IntroductionPatients with the ultra-rare Wolfram syndrome (WFS) develop insulin-dependent diabetes and progressive neurodegeneration. The aim of the study was to quantify microRNAs (miRNAs) in sera from patients with WFS, correlate their expression with neurological imaging over time and compare miRNA levels with those observed in patients with type 1 diabetes mellitus (T1DM).Research design and methodsWe quantified miRNA expression (Qiagen, Germany) in two groups of patients: with WFS at study entry (n=14) and after 2 years of follow-up and in 15 glycated hemoglobin-matched (p=0.72) patients with T1DM.ResultsWe observed dynamic changes in the expression of multiple miRNAs in patients with WFS parallel to disease progression and in comparison to the T1DM patients group. Among miRNAs that differed between baseline and follow-up WFS samples, the level of 5 increased over time (miR-375, miR-30d-5p, miR-30e-30, miR-145-5p and miR-193a-5p) and was inversely correlated with macular average thickness, while the expression of 2 (let-7g-5p and miR-22-3p) decreased and was directly correlated with neuroimaging indicators of neurodegeneration.ConclusionsOur findings show for the first time that serum miRNAs can be used as easily accessible indicators of disease progression in patients with WFS, potentially facilitating clinical trials on mitigating neurodegeneration. |
| اللغة: | English |
| تدمد: | 2052-4897 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb47cc262d4c0f7b169ba7b330493ae5Test http://europepmc.org/articles/PMC7607591Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cb47cc262d4c0f7b169ba7b330493ae5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20524897 |
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