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1دورية أكاديمية
المؤلفون: Abuabara, Katrina, Silverberg, Jonathan I, Simpson, Eric L, Paller, Amy S, Eichenfield, Lawrence F, Bissonnette, Robert, Krueger, James, Harris, John E, Dalfonso, Laura, Watkins, Stephanie E, Crawford, Julie M, Thaçi, D, Guttman-Yassky, Emma
المصدر: BMJ open. 10(11)
مصطلحات موضوعية: eczema, medical history, statistics & research methods, therapeutics, statistics &, research methods, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
الوصف: IntroductionAs new topical and systemic treatments become available for atopic dermatitis (AD), there is a need to understand how treatments are being used in routine clinical practice, their comparative effectiveness and their long-term safety in diverse clinical settings.Methods and analysisThe TARGET-DERM AD cohort is a longitudinal, observational study of patients with AD of all ages, designed to provide practical information on long-term effectiveness and safety unobtainable in traditional registration trials. Patients with physician-diagnosed AD receiving prescription treatment (topical or systemic) will be enrolled at academic and community clinical centres. Up to 3 years of retrospective medical records, 5 years of prospective medical records, and optional biological samples and patient-reported outcomes will be collected. The primary aims include characterisation of AD treatment regimens, evaluation of response to therapy, and description of adverse events.Ethics and disseminationTARGET-DERM has been approved by a central IRB (Copernicus Group IRB, 5000 Centregreen Way Suite 200, Cary, North Carolina 27513) as well as local and institutional IRBs. No additional Ethics Committee reviews. Results will be reviewed by a publications committee and submitted to peer-reviewed journals.Trial registration numberNCT03661866, pre-results.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/7x55j3pnTest
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2دورية أكاديمية
المؤلفون: Abuabara, Katrina, Silverberg, Jonathan I, Simpson, Eric L, Paller, Amy S, Eichenfield, Lawrence F, Bissonnette, Robert, Krueger, James, Harris, John E, Dalfonso, Laura, Watkins, Stephanie E, Crawford, Julie M, Thaçi, D, Guttman-Yassky, Emma
المصدر: BMJ open. 10(11)
مصطلحات موضوعية: Humans, Dermatitis, Atopic, Retrospective Studies, Prospective Studies, North Carolina, eczema, medical history, statistics & research methods, therapeutics, Clinical Research, Patient Safety, Comparative Effectiveness Research, Clinical Trials and Supportive Activities, Evaluation of treatments and therapeutic interventions, 6.1 Pharmaceuticals, statistics &, research methods, Clinical Sciences, Public Health and Health Services, Other Medical and Health Sciences
الوصف: IntroductionAs new topical and systemic treatments become available for atopic dermatitis (AD), there is a need to understand how treatments are being used in routine clinical practice, their comparative effectiveness and their long-term safety in diverse clinical settings.Methods and analysisThe TARGET-DERM AD cohort is a longitudinal, observational study of patients with AD of all ages, designed to provide practical information on long-term effectiveness and safety unobtainable in traditional registration trials. Patients with physician-diagnosed AD receiving prescription treatment (topical or systemic) will be enrolled at academic and community clinical centres. Up to 3 years of retrospective medical records, 5 years of prospective medical records, and optional biological samples and patient-reported outcomes will be collected. The primary aims include characterisation of AD treatment regimens, evaluation of response to therapy, and description of adverse events.Ethics and disseminationTARGET-DERM has been approved by a central IRB (Copernicus Group IRB, 5000 Centregreen Way Suite 200, Cary, North Carolina 27513) as well as local and institutional IRBs. No additional Ethics Committee reviews. Results will be reviewed by a publications committee and submitted to peer-reviewed journals.Trial registration numberNCT03661866, pre-results.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/7x55j3pnTest