Role of endoscopic ultrasonography in the diagnostic work-up of idiopathic acute pancreatitis (PICUS)
| العنوان: | Role of endoscopic ultrasonography in the diagnostic work-up of idiopathic acute pancreatitis (PICUS) |
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| المؤلفون: | Adriaan C.I.T.L. Tan, Chantal V Hoge, Tessa E H Römkens, Annemieke Y. Thijssen, Niels G. Venneman, Stefan A W Bouwense, G. Willemien Erkelens, Jan-Werner Poley, Marc G. Besselink, Nora D L Hallensleben, Sjoerd D. Kuiken, Rina A Bijlsma, Menno A. Brink, Akin Inderson, Wouter L. Hazen, Hjalmar C. van Santvoort, Hendrik M. van Dullemen, Erwin J M van Geenen, Brechje C van Eijck, Marja A. Boermeester, Jeanin E van Hooft, Ben J.M. Witteman, Marie-Paule Anten, Devica S Umans, Lieke Hol, Lars E. Perk, Paul Fockens, Rutger Quispel, Marco J. Bruno, Annet M. C. J. Voorburg, Frank P. Vleggaar, Roy L.J. van Wanrooij, Hester C. Timmerhuis, Robert C. Verdonk, Wouter L. Curvers, Liesbeth M. Kager, Abha Bhalla |
| المساهمون: | MUMC+: MA Heelkunde (9), Interne Geneeskunde, MUMC+: MA Maag Darm Lever (9), RS: FHML non-thematic output, Center for Liver, Digestive and Metabolic Diseases (CLDM), Gastroenterology & Hepatology, Gastroenterology and Hepatology, Graduate School, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Surgery |
| المصدر: | BMJ Open, 10(8):035504. BMJ Publishing Group BMJ Open, Vol 10, Iss 8 (2020) BMJ Open, 10, 8 BMJ Open, 10(8). BMJ PUBLISHING GROUP BMJ Open, 10(8):e035504. BMJ PUBLISHING GROUP BMJ Open, 10(8):e035504. BMJ Publishing Group BMJ open, 10(8). BMJ Publishing Group BMJ Open BMJ Open, 10 |
| بيانات النشر: | BMJ PUBLISHING GROUP, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, etiology, infected necrotizing pancreatitis, Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0], Gastroenterology and Hepatology, magnetic-resonance cholangiopancreatography, hepatobiliary disease, Endosonography, Recurrent pancreatitis, All institutes and research themes of the Radboud University Medical Center, GALLSTONE PANCREATITIS, medicine, Tumours of the digestive tract Radboud Institute for Molecular Life Sciences [Radboudumc 14], MANAGEMENT, Humans, Multicenter Studies as Topic, EPIDEMIOLOGY, Prospective Studies, endoscopy, Prospective cohort study, EUS, Netherlands, First episode, COMPLICATIONS, ATLANTA CLASSIFICATION, business.industry, ultrasound, Hepatobiliary disease, General Medicine, Guideline, medicine.disease, Reconstructive and regenerative medicine Radboud Institute for Molecular Life Sciences [Radboudumc 10], Pancreatitis, Acute Disease, Emergency medicine, Good clinical practice, Quality of Life, Acute pancreatitis, Medicine, business, pancreatic disease |
| الوصف: | IntroductionIdiopathic acute pancreatitis (IAP) remains a dilemma for physicians as it is uncertain whether patients with IAP may actually have an occult aetiology. It is unclear to what extent additional diagnostic modalities such as endoscopic ultrasonography (EUS) are warranted after a first episode of IAP in order to uncover this aetiology. Failure to timely determine treatable aetiologies delays appropriate treatment and might subsequently cause recurrence of acute pancreatitis. Therefore, the aim of the Pancreatitis of Idiopathic origin: Clinical added value of endoscopic UltraSonography (PICUS) Study is to determine the value of routine EUS in determining the aetiology of pancreatitis in patients with a first episode of IAP.Methods and analysisPICUS is designed as a multicentre prospective cohort study of 106 patients with a first episode of IAP after complete standard diagnostic work-up, in whom a diagnostic EUS will be performed. Standard diagnostic work-up will include a complete personal and family history, laboratory tests including serum alanine aminotransferase, calcium and triglyceride levels and imaging by transabdominal ultrasound, magnetic resonance imaging or magnetic resonance cholangiopancreaticography after clinical recovery from the acute pancreatitis episode. The primary outcome measure is detection of aetiology by EUS. Secondary outcome measures include pancreatitis recurrence rate, severity of recurrent pancreatitis, readmission, additional interventions, complications, length of hospital stay, quality of life, mortality and costs, during a follow-up period of 12 months.Ethics and disseminationPICUS is conducted according to the Declaration of Helsinki and Guideline for Good Clinical Practice. Five medical ethics review committees assessed PICUS (Medical Ethics Review Committee of Academic Medical Center, University Medical Center Utrecht, Radboud University Medical Center, Erasmus Medical Center and Maastricht University Medical Center). The results will be submitted for publication in an international peer-reviewed journal.Trial registration numberNetherlands Trial Registry (NL7066). Prospectively registered. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2044-6055 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd8e44a74970e541acc2e520c20612dcTest https://research.rug.nl/en/publications/638bddc8-9fd5-4a39-b6c2-c863496c847eTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dd8e44a74970e541acc2e520c20612dc |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20446055 |
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