Piloting gender-oriented colorectal cancer screening with a faecal immunochemical test: population-based registry study from Finland
| العنوان: | Piloting gender-oriented colorectal cancer screening with a faecal immunochemical test: population-based registry study from Finland |
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| المؤلفون: | Nea Malila, Milla Lehtinen, Sirpa Heinävaara, Maija Jäntti, Lotta Patrikka, Ahti Anttila, Marja Hyöty, Matti Kairaluoma, Tero Rautio, Martti Färkkilä, Sanni Helander, Markku Voutilainen, Tytti Sarkeala |
| المساهمون: | Centre of Excellence in Complex Disease Genetics, HUS Abdominal Center, Department of Medicine, Clinicum, Gastroenterologian yksikkö, Tampere University, Department of Gastroenterology, Health Sciences |
| المصدر: | BMJ Open, Vol 11, Iss 2 (2021) BMJ Open |
| بيانات النشر: | BMJ, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Colorectal cancer, Population, gastroenterology, 3121 Internal medicine, Screening programme, Feces, Hemoglobins, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Epidemiology, Humans, Mass Screening, Medicine, Registries, education, Early Detection of Cancer, Finland, Aged, education.field_of_study, business.industry, Crc screening, public health, health policy, Colonoscopy, General Medicine, Middle Aged, medicine.disease, 3. Good health, Test (assessment), 3141 Health care science, Colorectal cancer screening, Occult Blood, 3121 General medicine, internal medicine and other clinical medicine, 030220 oncology & carcinogenesis, Female, epidemiology, 030211 gastroenterology & hepatology, Colorectal Neoplasms, business, Population-Based Registry |
| الوصف: | ObjectiveTo assess the feasibility and evaluate the performance of a relaunched colorectal cancer (CRC) screening programme with different cut-offs for men and women.DesignPopulation-based registry study.SettingNine municipalities in Finland which started CRC screening with faecal immunochemical test (FIT) in April 2019 with cut-off levels 70 µg Hg/g faeces for men and 25 µg Hg/g faeces for women.ParticipantsMen (n=13 059) and women (n=14 669) aged 60–66 years invited to screening during the first programme year.Outcome measuresParticipation rates, positivity rates, detection rates of CRC and advanced adenoma (AA), and positive predictive values (PPV) of FIT for CRC and AA.ResultsAltogether 21 993 invitees returned stool samples. The participation rate of women (83.4%; 95% CI 82.8 to 84.0) was significantly higher than that of men (74.7%; 95% CI 73.9 to 75.4). The positivity rates were 2.4% (2.2 to 2.7) and 2.8% (2.5 to 3.1), respectively. In total, 37 CRCs and 116 AAs were detected. The detection rates of CRC and AA per 1000 participants were 1.8 (1.1 to 2.9) and 7.2 (5.6 to 9.1) for men and 1.6 (0.9 to 2.4) and 3.8 (2.8 to 5.0) for women. The PPVs per 100 positive tests were 6.6 (4.0 to 10.3) and 25.7 (20.6 to 31.4) for men and 6.4 (3.9 to 9.8) and 15.5 (11.6 to 20.2) for women.ConclusionsThe chosen FIT strategy narrowed the gap in the diagnostic performance between men and women especially in the detection of CRC. The participation rates were excellent. The levels of positivity and detection rates were moderate and need further action. The results indicate that gender-specific protocols can be introduced to organised CRC screening. It is yet to be seen whether they are more effective than a uniform screening protocol. |
| وصف الملف: | fulltext |
| تدمد: | 2044-6055 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fba1adc3d44c0c30b6d343dbe2fc414Test https://doi.org/10.1136/bmjopen-2020-046667Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5fba1adc3d44c0c30b6d343dbe2fc414 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20446055 |
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