Trends in excess mortality associated with atrial fibrillation over 45 years (Framingham Heart Study): community based cohort study
| العنوان: | Trends in excess mortality associated with atrial fibrillation over 45 years (Framingham Heart Study): community based cohort study |
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| المؤلفون: | Ludovic Trinquart, Emelia J. Benjamin, Lars Frost, Nicklas Vinter, Qiuxi Huang, Morten Fenger-Grøn |
| المصدر: | The BMJ Vinter, N, Huang, Q, Fenger-Grøn, M, Frost, L, Benjamin, E J & Trinquart, L 2020, ' Trends in excess mortality associated with atrial fibrillation over 45 years (Framingham Heart Study) : community based cohort study ', The BMJ, vol. 370, m2724 . https://doi.org/10.1136/bmj.m2724Test Vinter, N, Huang, Q, Fenger-Grøn, M, Frost, L, Benjamin, E J & Trinquart, L 2020, ' Trends in excess mortality associated with atrial fibrillation over 45 years (Framingham Heart Study) : community based cohort study ', B M J, vol. 370, m2724 . https://doi.org/10.1136/bmj.m2724Test |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Risk Assessment, Electrocardiography, Framingham Heart Study, Risk Factors, Internal medicine, Cause of Death, Atrial Fibrillation, Medicine, Humans, Longitudinal Studies, Aged, Aged, 80 and over, Framingham Risk Score, business.industry, Incidence (epidemiology), Incidence, Research, Hazard ratio, Atrial fibrillation, General Medicine, Middle Aged, medicine.disease, Survival Rate, Massachusetts, Cohort, Cardiology, Female, business, Atrial flutter, Cohort study |
| الوصف: | ObjectiveTo assess temporal trends in the association between newly diagnosed atrial fibrillation and death.DesignCommunity based cohort study.SettingFramingham Heart Study cohort, in 1972-85, 1986-2000, and 2001-15 (periods 1-3, respectively), in Framingham, MA, USA.ParticipantsParticipants with no atrial fibrillation, aged 45-95 in each time period, and identified with newly diagnosed atrial fibrillation (or atrial flutter) during each time period.Main outcome measuresThe main outcome was all cause mortality. Hazard ratios for the association between time varying atrial fibrillation and all cause mortality were calculated with adjustment for time varying confounding factors. The difference in restricted mean survival times, adjusted for confounders, between participants with atrial fibrillation and matched referents at 10 years after a diagnosis of atrial fibrillation was estimated. Meta-regression was used to test for linear trends in hazard ratios and restricted mean survival times over the different time periods.Results5671 participants were selected in time period 1, 6177 in period 2, and 6174 in period 3. Adjusted hazard ratios for all cause mortality between participants with and without atrial fibrillation were 1.9 (95% confidence interval 1.7 to 2.2) in time period 1, 1.4 (1.3 to 1.6) in period 2, and 1.7 (1.5 to 2.0) in period 3 (Ptrend=0.70). Ten years after diagnosis of atrial fibrillation, the adjusted difference in restricted mean survival times between participants with atrial fibrillation and matched referents decreased by 31%, from −2.9 years (95% confidence interval −3.2 to −2.5) in period 1, to −2.1 years (−2.4 to −1.8) in period 2, to −2.0 years (−2.3 to −1.7) in period 3 (Ptrend=0.03).ConclusionsNo evidence of a temporal trend in hazard ratios for the association between atrial fibrillation and all cause mortality was found. The mean number of life years lost to atrial fibrillation at 10 years had improved significantly, but a two year gap compared with individuals without atrial fibrillation still remained. |
| وصف الملف: | application/pdf |
| تدمد: | 1756-1833 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b87dda59832bdec0e4463fb6fea02e2dTest https://pubmed.ncbi.nlm.nih.gov/32784208Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b87dda59832bdec0e4463fb6fea02e2d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17561833 |
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