Comparison of the fecal bacterial microbiota of healthy and diarrheic foals at two and four weeks of life
| العنوان: | Comparison of the fecal bacterial microbiota of healthy and diarrheic foals at two and four weeks of life |
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| المؤلفون: | Mohammad Taha Jalali, Henry R. Staempfli, Luca Guardabassi, J. S. Weese, Angelika Schoster |
| المساهمون: | University of Zurich, Schoster, Angelika |
| المصدر: | BMC Veterinary Research, Vol 13, Iss 1, Pp 1-10 (2017) BMC Veterinary Research Schoster, A, Staempfli, H R, Guardabassi, L G, Jalali, M & Weese, J S 2017, ' Comparison of the fecal bacterial microbiota of healthy and diarrheic foals at two and four weeks of life ', B M C Veterinary Research, vol. 13, 144 . https://doi.org/10.1186/s12917-017-1064-xTest |
| بيانات النشر: | BMC, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Diarrhea, Male, 0301 basic medicine, Veterinary medicine, Ruminococcaceae, 040301 veterinary sciences, 3400 General Veterinary, animal diseases, Biology, Horse, digestive system, 0403 veterinary science, Feces, 03 medical and health sciences, Lachnospiraceae, parasitic diseases, medicine, Animals, Horses, Gastrointestinal microbiota, Clostridiales, lcsh:Veterinary medicine, General Veterinary, 630 Agriculture, 04 agricultural and veterinary sciences, General Medicine, Gastrointestinal Microbiome, Young age, 030104 developmental biology, Animals, Newborn, 570 Life sciences, biology, lcsh:SF600-1100, Female, Horse Diseases, 10090 Equine Department, medicine.symptom, Metagenomic sequencing, Research Article |
| الوصف: | Background Diarrhea in foals affects up to 60% of foals during the first six months of life. The effect of diarrhea on the fecal bacterial microbiota in foals has not been investigated. Little is known on the fecal bacterial microbial richness and diversity of foals at a young age. The objective was to compare the fecal bacterial microbiota of healthy foals to foals with diarrhea at two and four weeks of life. Methods Fecal samples were collected from foals (n = 20) at 1–14 (T1) and 15–28 (T2) days of age and analyzed using high throughput sequencing. Differences in relative abundance of bacterial taxa, alpha diversity and beta diversity indices were assessed between age-matched foals with diarrhea (n = 9) and healthy foals (n = 11), and between time points. Results Differences in microbial community composition based on time point and health status were observed on all taxonomic levels. Of 117 enriched species in healthy foals at T2, 50 (48%) were Lachnospiraceae or Ruminococcaceae. The Chao richness index was increased in healthy foals at T2 compared to T1 (p = 0.02). Foals with diarrhea had a significantly lower richness index than non-diarrheic foals at T2 (p = 0.04). Diarrhea had an inconsistent effect, while time point had a consistent effect on microbial community structure. Conclusions Preventative and therapeutic measures for diarrhea should focus on maintaining bacterial microbiota richness. Lachnospiraceae and Ruminococcaceae were underrepresented in foals with diarrhea. These should be evaluated further as potential therapeutic options. Electronic supplementary material The online version of this article (doi:10.1186/s12917-017-1064-x) contains supplementary material, which is available to authorized users. |
| وصف الملف: | Schoster_2017_(BMC_Vet_Res)_Microbiota_foals_diarrhea_vs_healthy.pdf - application/pdf; application/pdf |
| اللغة: | English |
| تدمد: | 1746-6148 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a040a288fd01177f63686ea62e44430Test http://link.springer.com/article/10.1186/s12917-017-1064-xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1a040a288fd01177f63686ea62e44430 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17466148 |
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