Adults with Prader–Willi syndrome exhibit a unique microbiota profile
| العنوان: | Adults with Prader–Willi syndrome exhibit a unique microbiota profile |
|---|---|
| المؤلفون: | Thomas A. Tompkins, Jeremie Auger, Wendy J. Dahl, Zainab Alyousif, Jennifer L. Miller |
| المصدر: | BMC Research Notes, Vol 14, Iss 1, Pp 1-7 (2021) BMC Research Notes |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Blautia, Prader–Willi syndrome, Gastrointestinal transit time, Adult population, lcsh:Medicine, Zoology, Body weight, General Biochemistry, Genetics and Molecular Biology, Body Mass Index, 03 medical and health sciences, 0302 clinical medicine, RNA, Ribosomal, 16S, Humans, RF39, 16S rRNA, lcsh:Science (General), Alistipes, lcsh:QH301-705.5, Metabolic health, Tenericutes, biology, Microbiota, Body Weight, lcsh:R, nutritional and metabolic diseases, General Medicine, biology.organism_classification, nervous system diseases, Research Note, 030104 developmental biology, lcsh:Biology (General), Amplicon sequencing, 030211 gastroenterology & hepatology, Prader-Willi Syndrome, lcsh:Q1-390, Ruminococcaceae |
| الوصف: | Objective Adults with Prader–Willi syndrome (PWS) require less energy intake to maintain body weight than the general adult population. This, combined with their altered gastrointestinal transit time, may impact microbiota composition. The aim of the study was to determine if the fecal microbiota composition of adults with PWS differed from non-affected adults. Using usual diet/non-interventional samples, fecal microbiota composition was analyzed using 16S rRNA gene amplicon sequencing and data from adults with PWS were merged with four other adult cohorts that differed by geographical location and age. QIIME 2™ sample-classifier, machine learning algorithms were used to cross-train the samples and predict from which dataset the taxonomic profiles belong. Taxa that most distinguished between all datasets were extracted and a visual inspection of the R library PiratePlots was performed to select the taxa that differed in abundance specific to PWS. Results Fecal microbiota composition of adults with PWS showed low Blautia and enhanced RF39 (phyla Tenericutes), Ruminococcaceae, Alistipes, Erysipelotrichacaea, Parabacteriodes and Odoribacter. Higher abundance of Tenericutes, in particular, may be a signature characteristic of the PWS microbiota although its relationship, if any, to metabolic health is not yet known. |
| تدمد: | 1756-0500 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c67e787f42f2cc3908b879509075ba3aTest https://doi.org/10.1186/s13104-021-05470-6Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c67e787f42f2cc3908b879509075ba3a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17560500 |
|---|